Invariant NKT cells sustain specific B cell responses and memory
| Autor: | Simona Tavarini, Sandra Nuti, Rino Rappuoli, Gianfranco Volpini, Marco Tortoli, Yasushi Uematsu, Elena Tonti, Giulia Casorati, Oretta Finco, Carmine Malzone, Paola Pittoni, Paolo Dellabona, Grazia Galli, Domenico Maione, Sergio Abrignani |
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| Rok vydání: | 2007 |
| Předmět: |
CD4-Positive T-Lymphocytes
Time Factors T cell Lymphocyte Galactosylceramides Mice Transgenic Antigens CD1 Mice Immune system Orthomyxoviridae Infections Antigen Immunity medicine Animals B cell B-Lymphocytes Mice Inbred BALB C Mice Inbred C3H MHC class II Multidisciplinary biology Biological Sciences Natural killer T cell Killer Cells Natural Mice Inbred C57BL medicine.anatomical_structure Immune System Immunology biology.protein Antigens CD1d Immunologic Memory |
| Zdroj: | Proceedings of the National Academy of Sciences. 104:3984-3989 |
| ISSN: | 1091-6490 0027-8424 |
| DOI: | 10.1073/pnas.0700191104 |
| Popis: | Invariant natural killer T (iNKT) cells are innate-like lymphocytes recognizing CD1d-restricted glycolipid antigens, such as α-galactosylceramide (αGC). We assessed whether iNKT cells help B lymphocyte responses and found that mice immunized with proteins and αGC develop antibody titers 1–2 logs higher than those induced by proteins alone. Activation of iNKT cells enhances protection against infections such as influenza and elicits higher frequencies of memory B cells and higher antibody responses to booster immunizations. Protein vaccination with αGC, but not with conventional adjuvants, elicits IgG responses in mice lacking MHC class II molecules, demonstrating that iNKT cells can substitute for CD4 + T cell help to B cells. Interestingly, the decay of circulating antibodies is faster in mice lacking iNKT cells. These findings point to a homeostatic role for iNKT cells on critical features of the antibody response such as immunity and B cell memory. |
| Databáze: | OpenAIRE |
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