Low serum magnesium and 1-year mortality in alcohol withdrawal syndrome

Autor: Dinesh Talwar, John Paul Leach, Donald C. McMillan, George Benson, Scott Dickson, Ewan Forrest, Donogh Maguire, Marylynne Woods, Hina Naz Abbasi, Tong Kwok, Benjamin Scally, David P. Ross, David Young, Luke Y. Zhu, Isla Waterson
Rok vydání: 2018
Předmět:
Male
Clinical Biochemistry
HA
030204 cardiovascular system & hematology
Biochemistry
Gastroenterology
Severity of Illness Index
Benzodiazepines
0302 clinical medicine
Risk Factors
Magnesium
030212 general & internal medicine
Young adult
Aged
80 and over
Age Factors
Alanine Transaminase
General Medicine
Middle Aged
Prognosis
Substance Withdrawal Syndrome
C-Reactive Protein
Alcohol withdrawal syndrome
Thiamine
Female
Adult
medicine.medical_specialty
medicine.drug_class
Proton-pump inhibitor
chemistry.chemical_element
03 medical and health sciences
Young Adult
Internal medicine
Severity of illness
medicine
Humans
Aspartate Aminotransferases
Mortality
Serum Albumin
Aged
Retrospective Studies
Benzodiazepine
Ethanol
business.industry
Platelet Count
Sodium
Central Nervous System Depressants
Retrospective cohort study
Bilirubin
Proton Pump Inhibitors
medicine.disease
Alkaline Phosphatase
Logistic Models
chemistry
Scotland
Multivariate Analysis
business
Magnesium Deficiency
Zdroj: European journal of clinical investigationREFERENCES. 49(9)
ISSN: 1365-2362
0014-2972
Popis: Background:\ud In 2014, the WHO reported that 6% of all deaths were attributable to excess alcohol consumption. The aim of the present study was to examine the relationship between serum magnesium concentrations and mortality in patients with alcohol withdrawal syndrome (AWS).\ud \ud Materials and methods:\ud A retrospective review of 700 patients with documented evidence of previous AWS indicating a requirement for benzodiazepine prophylaxis or evidence of alcohol withdrawal syndrome between November 2014 and March 2015.\ud \ud Results:\ud Of 380 patients included in the sample analysis, 64 (17%) were dead at 1 year following the time of treatment for AWS. The majority of patients had been prescribed thiamine (77%) and a proton pump inhibitor (66%). In contrast, the majority of patients had low circulating magnesium concentrations (2 (P < 0.001), sodium (P < 0.05), magnesium (P < 0.001), platelets (P < 0.05) and the use of proton pump inhibitor medication (P < 0.001) were associated with death at 1 year. On multivariate binary logistic regression analysis, age > 50 years (OR 3.37, 95% CI 1.52‐7.48, P < 0.01), AST:ALT ratio >2 (OR 3.10, 95% CI 1.38‐6.94, P < 0.01) and magnesium < 0.75 mmol/L (OR 4.11, 95% CI 1.3‐12.8, P < 0.05) remained independently associated with death at 1 year.\ud \ud Conclusion:\ud Overall, 1‐year mortality was significantly higher among those patients who were magnesium deficient (
Databáze: OpenAIRE
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