Effects of intensive insulin therapy combined with low molecular weight heparin anticoagulant therapy on severe pancreatitis
| Autor: | Hua-Bo Jiao, Hui-nan Yin, Shouwang Cai, Jun-dong Du, Zi-Man Zhu, Zhan‑Liang Li, Jing-Wang Tan, Yong-Ming Yao, Zhi-qiang Huang, Xi Zheng |
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| Rok vydání: | 2013 |
| Předmět: |
Cancer Research
medicine.medical_specialty medicine.drug_class medicine.medical_treatment Serum albumin Blood sugar Low molecular weight heparin Gastroenterology intensive insulin therapy Immunology and Microbiology (miscellaneous) White blood cell Internal medicine medicine diastase low molecular weight heparin anticoagulant therapy intestinal function recovery time albumin Prothrombin time biology medicine.diagnostic_test business.industry Insulin General Medicine Articles medicine.disease Surgery medicine.anatomical_structure biology.protein Acute pancreatitis Pancreatitis white blood cell business severe acute pancreatitis |
| Zdroj: | Experimental and Therapeutic Medicine |
| ISSN: | 1792-0981 |
| Popis: | The current study explored the effects of intensive insulin therapy (IIT) combined with low molecular weight heparin (LMWH) anticoagulant therapy on severe acute pancreatitis (SAP). A total of 134 patients with SAP that received treatment between June 2008 and June 2012 were divided randomly into groups A (control; n=33), B (IIT; n=33), C (LMWH; n=34) and D (IIT + LMWH; n=34). Group A were treated routinely. Group B received continuous pumped insulin, as well as the routine treatment, to maintain the blood sugar level between 4.4 and 6.1 mmol/l. Group C received a subcutaneous injection of LMWH every 12 h in addition to the routine treatment. Group D received IIT + LMWH and the routine treatment. The white blood cell count, hemodiastase, serum albumin, arterial partial pressure of oxygen and prothrombin time were recorded prior to treatment and 1, 3, 5, 7 and 14 days after the initiation of treatment. The intestinal function recovery time, incidence rate of multiple organ failure (MOF), length of hospitalization and fatality rates were observed. IIT + LMWH noticeably increased the white blood cell count, hemodiastase level, serum albumin level and the arterial partial pressure of oxygen in the patients with SAP (P0.05). IIT + LMWH had a noticeably improved clinical curative effect on SAP compared with that of the other treatments. |
| Databáze: | OpenAIRE |
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