The VEGF/Rho GTPase signalling pathway: A promising target for anti-angiogenic/anti-invasion therapy
| Autor: | Raymond M. Schiffelers, Gert Storm, Marc Symons, William M. Gallagher, Robert Kudernatsch, Robbert J. Kok, Annette T. Byrne, Roy van der Meel |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Vascular Endothelial Growth Factor A
rho GTP-Binding Proteins Angiogenesis VEGF receptors Angiogenesis Inhibitors Antineoplastic Agents GTPase chemistry.chemical_compound Drug Delivery Systems Neoplasms Drug Discovery Animals Humans Neoplasm Invasiveness Neoplasm Metastasis Pharmacology Neovascularization Pathologic biology dGTPase Anti angiogenic Hedgehog signaling pathway Vascular endothelial growth factor chemistry Immunology Cancer research biology.protein Signal transduction Signal Transduction |
| Zdroj: | Drug Discovery Today. 16:219-228 |
| ISSN: | 1359-6446 |
| Popis: | It has become increasingly apparent that current antiangiogenic therapy elicits modest effects in clinical settings. In addition, it remains challenging to treat cancer metastasis through antiangiogenic regimes. Rho GTPases are essential for vascular endothelial growth factor (VEGF)-mediated angiogenesis and are involved in tumour cell invasion. This review discusses novel therapeutic strategies that interfere with Rho GTPase signalling and further explores this network as a target for anticancer therapy through interference with tumour angiogenesis and invasion. Recent findings describe the development of innovative Rho GTPase inhibitors. Positive clinical effects of Rho GTPase targeting in combination with conventional anticancer therapy is of increasing interest. |
| Databáze: | OpenAIRE |
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