Alcohol and genetic polymorphisms: effect on risk of alcohol-related cancer
| Autor: | Nathalie Druesne-Pecollo, Bertrand Tehard, Serge Hercberg, Yann Mallet, Paule Latino-Martel, Teresa Norat, Mariette Gerber |
|---|---|
| Přispěvatelé: | Unité de Recherche en Epidémiologie Nutritionnelle (UREN), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Sorbonne Paris Cité (USPC)-Université Paris 13 (UP13)-Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Institut National de la Recherche Agronomique (INRA), Institut National du Cancer (INCa), Centre Régional de Lutte contre le Cancer Oscar Lambret [Lille] (UNICANCER/Lille), Université Lille Nord de France (COMUE)-UNICANCER, Centre régional de lutte contre le cancer, Department of Epidemiology and Public Health, Imperial College London, Université Paris 13 (UP13)-Institut National de la Recherche Agronomique (INRA)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Lille-UNICANCER |
| Rok vydání: | 2009 |
| Předmět: |
Alcohol Drinking
[SDV]Life Sciences [q-bio] Aldehyde dehydrogenase Alcohol Bioinformatics 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Risk Factors Neoplasms Medicine Humans Genetic Predisposition to Disease Ethanol metabolism Methylenetetrahydrofolate Reductase (NADPH2) 030304 developmental biology ALDH2 Alcohol dehydrogenase Genetics 0303 health sciences Ethanol Polymorphism Genetic biology business.industry Acetaldehyde Alcohol Dehydrogenase ADH1B Cytochrome P-450 CYP2E1 Aldehyde Dehydrogenase 3. Good health Oncology chemistry 030220 oncology & carcinogenesis Case-Control Studies biology.protein business |
| Zdroj: | Lancet Oncology Lancet Oncology, Elsevier, 2009, 10 (2), pp.173-180. ⟨10.1016/S1470-2045(09)70019-1⟩ ResearcherID Lancet Oncology, 2009, 10 (2), pp.173-180. ⟨10.1016/S1470-2045(09)70019-1⟩ |
| ISSN: | 1474-5488 1470-2045 |
| DOI: | 10.1016/S1470-2045(09)70019-1⟩ |
| Popis: | International audience; Public health guidelines aim to limit the consumption of alcoholic beverages worldwide and the subsequent health burden. In particular, alcohol consumption is an avoidable risk factor for cancer. In human beings, ethanol in alcoholic drinks is mainly oxidised in the liver by alcohol dehydrogenases to acetaldehyde, and is further detoxified to acetate by aldehyde dehydrogenases. Functional variants in genes involved in alcohol metabolism result in differences between individuals in exposure to carcinogenic acetaldehyde, suggesting a possible interaction of genetic susceptibility and alcohol exposure in cancer. We reviewed available studies of the combined effects of alcohol drinking and genetic polymorphisms on alcohol-related cancer risk. Most available data were for polymorphisms in alcohol and folate metabolism. We give an overview of published studies on the combined effects of alcohol drinking and polymorphisms in genes for alcohol dehydrogenase (ADH), aldehyde dehydrogenase (ALDH), cytochrome P450 2E1, and methylene-tetrahydrofolate reductase on the risk of alcohol-related cancer. Current data lend support to a role of polymorphisms ADH1B and ALDH2 combined with alcohol consumption in cancer. Other available data are insufficient or inconclusive, highlighting the need for additional studies. |
| Databáze: | OpenAIRE |
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