Directional Optical Coherence Tomography Provides Accurate Outer Nuclear Layer and Henle Fiber Layer Measurements

Autor: Jan Kristine Bayabo, Robert F. Cooper, Jason A. Croskrey, Austin Roorda, Brandon J. Lujan, Joseph Carroll, Adam M. Dubis, Bhavna J. Antony, Jacque L. Duncan
Jazyk: angličtina
Rok vydání: 2015
Předmět:
Male
genetic structures
Neurodegenerative
Ophthalmology & Optometry
chemistry.chemical_compound
cones
Nerve Fibers
Prospective Studies
outer plexiform layer
Tomography
screening and diagnosis
medicine.diagnostic_test
Fourier Analysis
Henle's fiber layer
photoreceptors
General Medicine
Healthy Volunteers
Detection
Fourier domain
medicine.anatomical_structure
Biomedical Imaging
biomarker
Female
spectral domain
Tomography
Optical Coherence
4.2 Evaluation of markers and technologies
Retinal Neurons
Adult
Adolescent
Ependymoglial Cells
Outer plexiform layer
Spectral domain
Article
Young Adult
rods
Optics
Optical coherence tomography
Opthalmology and Optometry
Henle fiber layer
medicine
Humans
Outer nuclear layer
Eye Disease and Disorders of Vision
Cell Nucleus
business.industry
Retinal
eye diseases
Ophthalmology
directional reflectivity
chemistry
Optical Coherence
sense organs
business
Zdroj: Lujan, BJ; Roorda, A; Croskrey, JA; Dubis, AM; Cooper, RF; Bayabo, JK; et al.(2015). Directional Optical Coherence Tomography Provides Accurate Outer Nuclear Layer and Henle Fiber Layer Measurements. Retina, 35(8), 1511-1520. doi: 10.1097/IAE.0000000000000527. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/3j2881wn
Retina (Philadelphia, Pa.), vol 35, iss 8
Popis: Copyright © by Ophthalmic Communications Society, Inc. Purpose: The outer nuclear layer (ONL) contains photoreceptor nuclei, and its thickness is an important biomarker for retinal degenerations. Accurate ONL thickness measurements are obscured in standard optical coherence tomography (OCT) images because of Henle fiber layer (HFL). Improved differentiation of the ONL and HFL boundary is made possible by using directional OCT, a method that purposefully varies the pupil entrance position of the OCT beam. Methods: Fifty-seven normal eyes were imaged using multiple pupil entry positions with a commercial spectral domain OCT system. Cross-sectional image sets were registered to each other and segmented at the top of HFL, the border of HFL and the ONL and at the external limiting membrane. Thicknesses of the ONL and HFL were measured and analyzed. Results: The true ONL and HFL thicknesses varied substantially by eccentricity and between individuals. The true macular ONL thickness comprised an average of 54.6% of measurements that also included HFL. The ONL and HFL thicknesses at specific retinal eccentricities were poorly correlated. Conclusion: Accurate ONL and HFL thickness measurements are made possible by the optical contrast of directional OCT. Distinguishing these individual layers can improve clinical trial endpoints and assessment of disease progression.
Databáze: OpenAIRE
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