Flexible spatial learning requires both the dorsal and ventral hippocampus and their functional interactions with the prefrontal cortex
| Autor: | Matthew L. Shapiro, Philip D. Avigan, Katharine M Cammack |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Dorsum Cognitive Neuroscience Spatial Learning Prefrontal Cortex Hippocampus Reversal Learning Article 050105 experimental psychology Temporal lobe 03 medical and health sciences 0302 clinical medicine Animals Rats Long-Evans 0501 psychology and cognitive sciences Discrimination learning Prefrontal cortex Episodic memory 05 social sciences Cognitive flexibility Rats nervous system Spatial learning Nerve Net Psychology Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Hippocampus |
| ISSN: | 1098-1063 1050-9631 |
| DOI: | 10.1002/hipo.23198 |
| Popis: | When faced with changing contingencies, animals can use memory to flexibly guide actions, engaging both frontal and temporal lobe brain structures. Damage to the hippocampus (HPC) impairs episodic memory, and damage to the prefrontal cortex (PFC) impairs cognitive flexibility, but the circuit mechanisms by which these areas support flexible memory processing remain unclear. The present study investigated these mechanisms by temporarily inactivating the medial PFC (mPFC), the dorsal HPC (dHPC), and the ventral HPC (vHPC), individually and in combination, as rats learned spatial discriminations and reversals in a plus maze. Bilateral inactivation of either the dHPC or vHPC profoundly impaired spatial learning and memory, whereas bilateral mPFC inactivation primarily impaired reversal versus discrimination learning. Inactivation of unilateral mPFC together with the contralateral dHPC or vHPC impaired spatial discrimination and reversal learning, whereas ipsilateral inactivation did not. Flexible spatial learning thus depends on both the dHPC and vHPC and their functional interactions with the mPFC. |
| Databáze: | OpenAIRE |
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