Establishment of reference intervals of clinical chemistry analytes for the adult population in Egypt

Autor: Dalia Ibrahim Ramadan, Ola Elgaddar, Sarah Aglan, Heba Baz, May Selim, Lamia Mansour, Kiyoshi Ichihara, Amina H Hassab, A. T. Awad
Rok vydání: 2020
Předmět:
Male
Physiology
Adult population
Biochemistry
Body Mass Index
Analytical Chemistry
Geographical Locations
Reference Values
Medicine and Health Sciences
Urea
Bile
Multidisciplinary
High prevalence
Organic Compounds
Middle Aged
C-Reactive Proteins
Lipids
Body Fluids
Chemistry
C-Reactive Protein
Cholesterol
Physiological Parameters
Physical Sciences
Medicine
Regression Analysis
Egypt
Female
Anatomy
Research Article
Adult
medicine.medical_specialty
Asia
Adolescent
Science
Direct bilirubin
Clinical Chemistry Tests
Young Adult
Chemical Analysis
Internal medicine
medicine
Humans
Triglycerides
Aged
Cholesterol
HDL
Body Weight
Organic Chemistry
Chemical Compounds
Biology and Life Sciences
Proteins
Bilirubin
medicine.disease
Obesity
Reference intervals
Age Groups
Reference values
People and Places
Africa
Weak association
Population Groupings
Body mass index
TBIL
Biomarkers
Zdroj: PLoS ONE
PLoS ONE, Vol 16, Iss 3, p e0236772 (2021)
ISSN: 1932-6203
Popis: Background This is the first Egyptian nationwide study for derivation of reference intervals (RIs) for 34 major chemistry analytes. It was conducted as a part of the global initiative by the IFCC Committee on Reference Intervals and Decision Limits (C-RIDL) for establishing country-specific RIs based on a harmonized protocol. Methods 691 apparently healthy volunteers aged ≥18 years were recruited from multiple regions in Egypt. Serum specimens were analyzed in two centers. The harmonization and standardization of test results were achieved by measuring value-assigned serum panel provided by C-RIDL. The RIs were calculated by parametric method. Sources of variation of reference values (RVs) were evaluated by multiple regression analysis. The need for partitioning by sex, age, and region was judged primarily by standard deviation ratio (SDR). Results Gender-specific RIs were required for six analytes including total bilirubin (TBil), aspartate and alanine aminotransferase (AST, ALT). Seven analytes required age-partitioning including glucose and low-density lipoprotein cholesterol (LDL-C). Regional differences were observed between northern and southern Egypt for direct bilirubin, glucose, and high-density-lipoprotein cholesterol (HDL-C) with all their RVs lower in southern Egypt. Compared with other collaborating countries, the features of Egyptian RVs were lower HDL-C and TBil and higher TG and C-reactive protein. In addition, BMI showed weak association with most of nutritional markers. These features were shared with two other Middle Eastern countries: Saudi Arabia and Turkey. Conclusion The standardized RIs established by this study can be used as common Egyptian RI, except for a few analytes that showed regional differences. Despite high prevalence of obesity among Egyptians, their RVs of nutritional markers are less sensitive to increased BMI, compared to other collaborating countries.
Databáze: OpenAIRE
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