Functions, mechanisms and regulation of Pumilio/Puf family RNA binding proteins: a comprehensive review
| Autor: | M. J. Nishanth, Bindu Simon |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Untranslated region Gene isoform Xenopus Arabidopsis Ribosome biogenesis RNA-binding protein Computational biology Biology 03 medical and health sciences Mice 0302 clinical medicine Genetics Animals Humans RNA Processing Post-Transcriptional Molecular Biology 3' Untranslated Regions Single-Stranded RNA Biological studies Three prime untranslated region RNA-Binding Proteins General Medicine 030104 developmental biology 030220 oncology & carcinogenesis Research questions |
| Zdroj: | Molecular biology reports. 47(1) |
| ISSN: | 1573-4978 |
| Popis: | The Pumilio (Pum)/Puf family proteins are ubiquitously present across eukaryotes, including yeast, plants and humans. They generally bind to the 3' untranslated regions of single stranded RNA targets in a sequence specific manner and destabilize them, although a few reports suggest their role in stabilizing the target transcripts. The Pum isoforms are implicated in a wide array of biological processes including stem cell maintenance, development, ribosome biogenesis as well as human diseases. Further studies on Pum would be interesting and important to understand their evolutionarily conserved and divergent features across species, which can have potential implications in medicine, plant sciences as well as basic molecular and cell biological studies. A large number of research reports exists, pertaining to various aspects of Pum, in individual experimental systems. This review is a comprehensive summary of the functions, types, mechanism of action as well as the regulation of Pum in various species. Also, the research questions to be addressed in future are discussed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink