Extracellular Matrix Disarray as a Mechanism for Greater Abdominal Versus Thoracic Aortic Stiffness With Aging in Primates
| Autor: | Zhe Sun, Gerald A. Meininger, Tara McNulty, Sanford P. Bishop, Li Chen, Dorothy E. Vatner, Jie Zhang, You-Tang Shen, Stephen F. Vatner, Xin Zhao |
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| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine Aging Aortic Diseases Aorta Thoracic macromolecular substances 030204 cardiovascular system & hematology Article 03 medical and health sciences Aortic aneurysm Vascular Stiffness 0302 clinical medicine medicine.artery Animals Medicine Thoracic aorta Arterial Pressure Aorta Abdominal biology business.industry Abdominal aorta Age Factors Anatomy medicine.disease Macaca mulatta Pathophysiology Elastin Extracellular Matrix Macaca fascicularis 030104 developmental biology Blood pressure Hypertension cardiovascular system biology.protein Aortic pressure Aortic stiffness Collagen Cardiology and Cardiovascular Medicine business |
| Zdroj: | Arteriosclerosis, Thrombosis, and Vascular Biology. 36:700-706 |
| ISSN: | 1524-4636 1079-5642 |
| DOI: | 10.1161/atvbaha.115.306563 |
| Popis: | Objective— Increased vascular stiffness is central to the pathophysiology of aging, hypertension, diabetes mellitus, and atherosclerosis. However, relatively few studies have examined vascular stiffness in both the thoracic and the abdominal aorta with aging, despite major differences in anatomy, embryological origin, and relation to aortic aneurysm. Approach and Results— The 2 other unique features of this study were (1) to study young (9±1 years) and old (26±1 years) male monkeys and (2) to study direct and continuous measurements of aortic pressure and thoracic and abdominal aortic diameters in conscious monkeys. As expected, aortic stiffness, β, was increased P Conclusions— Thus, aortic stiffness increases with aging as expected, but the most severe increases in aortic stiffness observed in the abdominal aorta is novel, where values in young monkeys equaled, or even exceeded, values of thoracic aortic stiffness in old monkeys. These results can be explained by alterations in collagen/elastin ratio, but even more importantly by collagen and elastin disarray. |
| Databáze: | OpenAIRE |
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