Newly diagnosed rheumatic heart disease among indigenous populations in the Pacific
| Autor: | Isabelle Missotte, Mariana Mirabel, Eloi Marijon, Baptiste Noël, Jean-Philippe Empana, Tom Parks, Thierry Jubeau, Gwendolyne Phelippeau, Corinne Braunstein, Xavier Jouven, Shirley Gervolino, Olivier Axler, Marie Nadra, Jacques Robert, Cécile Cazorla, Bernard Rouchon, Sylvie Laumond, Elodie Descloux, Yann Barguil, Muriel Tafflet |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Pediatrics medicine.medical_specialty Cardiac & Cardiovascular Systems Heart disease Adolescent Population Severity of Illness Index Cohort Studies FEVER New Caledonia Severity of illness Outcome Assessment Health Care medicine MANAGEMENT Secondary Prevention CRITERIA Humans Registries education INFECTIVE ENDOCARDITIS 1102 Cardiorespiratory Medicine and Haematology Demography education.field_of_study Science & Technology business.industry Incidence (epidemiology) Incidence Rheumatic Heart Disease 1103 Clinical Sciences medicine.disease Hospitalization Embolism Socioeconomic Factors Cardiovascular System & Hematology Cardiovascular Diseases Echocardiography Heart failure Valvular Heart Disease Cardiovascular System & Cardiology Female Cardiology and Cardiovascular Medicine business Life Sciences & Biomedicine Mace Cohort study CARDIAC-SURGERY |
| Zdroj: | Heart |
| Popis: | Objectives Rheumatic heart disease (RHD) remains the leading acquired heart disease in the young worldwide. We aimed at assessing outcomes and influencing factors in the contemporary era. Methods Hospital-based cohort in a high-income island nation where RHD remains endemic and the population is captive. All patients admitted with newly diagnosed RHD according to World Heart Federation echocardiographic criteria were enrolled (2005–2013). The incidence of major cardiovascular events (MACEs) including heart failure, peripheral embolism, stroke, heart valve intervention and cardiovascular death was calculated, and their determinants identified. Results Of the 396 patients, 43.9% were male with median age 18 years (IQR 10–40)). 127 (32.1%) patients presented with mild, 131 (33.1%) with moderate and 138 (34.8%) with severe heart valve disease. 205 (51.8%) had features of acute rheumatic fever. 106 (26.8%) presented with at least one MACE. Among the remaining 290 patients, after a median follow-up period of 4.08 (95% CI 1.84 to 6.84) years, 7 patients (2.4%) died and 62 (21.4%) had a first MACE. The annual incidence of first MACE and of heart failure were 59.05‰ (95% CI 44.35 to 73.75) and 29.06‰ (95% CI 19.29 to 38.82), respectively. The severity of RHD at diagnosis (moderate vs mild HR 3.39 (0.95 to 12.12); severe vs mild RHD HR 10.81 (3.11 to 37.62), p |
| Databáze: | OpenAIRE |
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