Unique structural properties of DNA interstrand cross-links formed by a new antitumor dinuclear Pt(ii ) complex
| Autor: | Ondrej Hrabina, Zijian Guo, Vojtech Novohradsky, Viktor Brabec, Jana Kasparkova, Tereza Suchankova |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Base Sequence Organoplatinum Compounds 030102 biochemistry & molecular biology Stereochemistry Chemistry Metals and Alloys Biophysics Antineoplastic Agents DNA Biochemistry Intercalating Agents Molecular Docking Simulation Biomaterials DNA Adducts 03 medical and health sciences chemistry.chemical_compound Cross-Linking Reagents 030104 developmental biology Chemistry (miscellaneous) hemic and lymphatic diseases Humans Nucleic Acid Conformation Structural motif |
| Zdroj: | Metallomics. 9:494-500 |
| ISSN: | 1756-591X 1756-5901 |
| DOI: | 10.1039/c7mt00052a |
| Popis: | The DNA interstrand cross-links of the antitumor drug {[cis-Pt(NH3)2Cl]2(4,4′-methylenedianiline)}2+ (1) play a prevalent role in its antitumor effects. Complex 1 forms DNA long-range interstrand cross-links uniquely in the 3′–3′ direction. Conformational distortions induced by these interstrand cross-links in DNA represent a potential structural motif for recognition by high-mobility-group proteins. |
| Databáze: | OpenAIRE |
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