Environmental enrichment mitigates the sex-specific effects of gestational inflammation on social engagement and the hypothalamic pituitary adrenal axis-feedback system
Autor: | Abdul Naveed Shaik, Amanda C. Kentner, Mattia M. Migliore, Eric J Connors |
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Rok vydání: | 2014 |
Předmět: |
Lipopolysaccharides
Male Hypothalamo-Hypophyseal System medicine.medical_specialty Offspring Immunology Pituitary-Adrenal System Hippocampus Context (language use) Environment Rats Sprague-Dawley Behavioral Neuroscience chemistry.chemical_compound Pregnancy Corticosterone Internal medicine medicine Animals Social Behavior Inflammation Sex Characteristics Environmental enrichment Behavior Animal Endocrine and Autonomic Systems medicine.disease Housing Animal Rats medicine.anatomical_structure Endocrinology chemistry Prenatal Exposure Delayed Effects Female Psychology Hypothalamic–pituitary–adrenal axis Sex characteristics |
Zdroj: | Brain, Behavior, and Immunity. 42:178-190 |
ISSN: | 0889-1591 |
Popis: | Modest environmental enrichment (EE) is well recognized to protect and rescue the brain from the consequences of a variety of insults. Although animal models of maternal immune activation (MIA) are associated with several neurodevelopmental impairments in both the behavioral and cognitive functioning of offspring, the impact of EE in protecting or reversing these effects has not been fully evaluated. In the present study, female Sprague-Dawley rats were randomized into EE (pair-housed in a large multi-level cage with toys, tubes and ramps) or animal care control (ACC; pair-housed in standard cages) conditions. Each pair was bred, following assignment to their housing condition, and administered 100μg/kg of lipopolysaccharide (LPS) on gestational day 11. After birth, and until the end of the study, offspring were maintained in their respective housing conditions. EE protected against both the social and hypothalamic pituitary adrenal axis consequences of MIA in juvenile male rats, but surprisingly not against the spatial discrimination deficits or accompanying decrease in glutamate levels within the hippocampus (as measured via LCMS-MS). Based on these preliminary results, the mechanisms that underlie the sex-specific consequences that follow MIA appear to be dependent on environmental context. Together, this work highlights the importance of environmental complexity in the prevention of neurodevelopmental deficits following MIA. |
Databáze: | OpenAIRE |
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