Participation of immune complexes in adenovirus infection
| Autor: | F M Thompson, A S Mistchenko, S Grinstein, C Navari, H L Lenzi, E M Mota, S Vidaurreta |
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| Rok vydání: | 1992 |
| Předmět: |
Male
viruses Fluorescent Antibody Technique Antigen-Antibody Complex Kidney Immunofluorescence Adenovirus Infections Human Immune system medicine Humans Adenovirus infection Lung Respiratory Tract Infections Retrospective Studies biology medicine.diagnostic_test business.industry Infant Respiratory infection General Medicine medicine.disease Virology medicine.anatomical_structure Child Preschool Pediatrics Perinatology and Child Health Immunology biology.protein Female Antibody business Respiratory tract |
| Zdroj: | Acta Paediatrica. 81:983-988 |
| ISSN: | 1651-2227 0803-5253 |
| DOI: | 10.1111/j.1651-2227.1992.tb12159.x |
| Popis: | To determine the participation of immune complexes during adenovirus infection, we evaluated serum and necropsy specimens of patients with confirmed adenovirus infection of the lower respiratory tract. In lung and kidney from seven dead patients, immunofluorescence revealed the presence of hexon, immunoglobulins and complement. These patients had clinical manifestations of kidney dysfunction. In dead patients (3/3 in whom serum was available) neither anti-adenovirus antibodies nor adenovirus-specific immune complexes could be found in the final stage of the infection. However, two of these patients had anti-adenovirus antibodies and immune complexes in samples obtained early in the infection. Most patients (16/19) who survived the infection had circulating anti-adenovirus antibodies. Half also had immune complexes specific for adenovirus in some moment of the illness. This suggests that immune complexes arise during respiratory infection by adenovirus, probably contributing to its clinical picture. |
| Databáze: | OpenAIRE |
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