Effects of Nifedipine on Placental Blood Flow, Placental Weight and Fetal Weight in Normotensive and Spontaneously Hypertensive Rats
| Autor: | Akira Yajima, H. Nagae, H Kimura, Nobuaki Furuhashi, M. Tsujiei |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
medicine.medical_specialty
Nifedipine Placenta Hemodynamics Rats Inbred WKY Fetus Spontaneously hypertensive rat Pre-Eclampsia Pregnancy Rats Inbred SHR Internal medicine medicine Animals cardiovascular diseases business.industry Obstetrics and Gynecology Blood flow Fetal weight Rats medicine.anatomical_structure Endocrinology Reproductive Medicine Regional Blood Flow cardiovascular system Pregnancy Animal Female business Placental blood circulatory and respiratory physiology medicine.drug |
| Zdroj: | Gynecologic and Obstetric Investigation. 34:193-196 |
| ISSN: | 1423-002X 0378-7346 |
| DOI: | 10.1159/000292759 |
| Popis: | The effect of nifedipine on placental blood flow was investigated in spontaneously hypertensive rats (SHR) and compared with that in normotensive Wistar Kyoto rats (WKY) by means of the clearance of hydrogen gas generated by electrolysis. The placental blood flow of nifedipine-treated WKY (5, 10 and 25 mg/kg) was significantly (p < 0.05) reduced compared with that of WKY control. On the other hand, the placental blood flow of nifedipine-treated SHR did not change compared with that of SHR control. These data suggest that nifedipine has different effects on placental blood flow in SHR and WKY. |
| Databáze: | OpenAIRE |
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