Screening of inmates transferred to Spain reveals a Peruvian prison as a reservoir of persistent Mycobacterium tuberculosis MDR strains and mixed infections

Autor: Viviana Ritacco, María Jesús Ruiz Serrano, Estefanía Abascal, Daniela Maria Cirillo, Johana Monteserin, Darío García de Viedma, Eduardo Gotuzzo, Marta Herranz, Pilar Gómez Pintado, Fermín Acosta, Enrique Acín, Álvaro Chiner-Oms, Juan Agapito, Paloma Gijón, Andrea M. Cabibbe, Nuria Lozano, Francisco Fernández-González, Eddy Valencia, Tatiana Cáceres, Patricia Muñoz, Iñaki Comas
Přispěvatelé: Instituto de Salud Carlos III, European Commission, Secretaría Nacional de Ciencia y Tecnología (Panamá), Comas, Iñaki [0000-0001-5504-9408], Chiner-Oms, Álvaro [0000-0002-0463-0101], Comas, Iñaki, Chiner-Oms, Álvaro
Rok vydání: 2020
Předmět:
0301 basic medicine
Latin Americans
Epidemiology
Antitubercular Agents
lcsh:Medicine
Prison
purl.org/pe-repo/ocde/ford#3.03.09 [https]
0302 clinical medicine
Drug Resistance
Multiple
Bacterial
Peru
Tuberculosis
Multidrug-Resistant
Prevalence
Mass Screening
lcsh:Science
media_common
purl.org/pe-repo/ocde/ford#3.03.08 [http]
Molecular Epidemiology
Multidisciplinary
biology
Coinfection
3. Good health
Bacterial Typing Techniques
Geography
population characteristics
Patient Transfer
medicine.medical_specialty
media_common.quotation_subject
030231 tropical medicine
Article
Mycobacterium tuberculosis
03 medical and health sciences
Environmental health
mental disorders
medicine
Humans
purl.org/pe-repo/ocde/ford#1.06.01 [https]
Clinical microbiology
Tuberculosis
Pulmonary
Mass screening
Molecular epidemiology
Prisoners
lcsh:R
social sciences
biology.organism_classification
medicine.disease
Multiple drug resistance
030104 developmental biology
Spain
purl.org/pe-repo/ocde/ford#3.02.07 [https]
Prisons
lcsh:Q
Zdroj: SCIENTIFIC REPORTS
r-FISABIO: Repositorio Institucional de Producción Científica
Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
Scientific Reports
CONCYTEC-Institucional
Consejo Nacional de Ciencia Tecnología e Innovación Tecnológica
instacron:CONCYTEC
r-FISABIO. Repositorio Institucional de Producción Científica
instname
Digital.CSIC. Repositorio Institucional del CSIC
Scientific Reports, Vol 10, Iss 1, Pp 1-8 (2020)
ISSN: 2045-2322
Popis: 8 páginas, 4 figuras, 1 tabla. Información suplementaria accesible en: https://doi.org/10.1038/s41598-020-59373-w
It is relevant to evaluate MDR-tuberculosis in prisons and its impact on the global epidemiology of this disease. However, systematic molecular epidemiology programs in prisons are lacking. A health-screening program performed on arrival for inmates transferred from Peruvian prisons to Spain led to the diagnosis of five MDR-TB cases from one of the biggest prisons in Latin America. They grouped into two MIRU-VNTR-clusters (Callao-1 and Callao-2), suggesting a reservoir of two prevalent MDR strains. A high-rate of overexposure was deduced because one of the five cases was coinfected by a pansusceptible strain. Callao-1 strain was also identified in 2018 in a community case in Spain who had been in the same Peruvian prison in 2002-5. A strain-specific-PCR tailored from WGS data was implemented in Peru, allowing the confirmation that these strains were currently responsible for the majority of the MDR cases in that prison, including a new mixed infection.
This work was supported by ERANet-LAC [ELAC2015/T08–0664, E035-ERANet-LAC/J110-2016/FONDECYT, PER-2012-ELAC2015/T08-0664] and Instituto de Salud Carlos III [AC16/00057, FIS15/01554, FIS13/01207] and cofunded by European Regional Development Funds from the European Commission: “A way of making Europe”. FA holds a grant from IFARHUSENACYT [270-2016-293].
Databáze: OpenAIRE
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