Association of serum α-tocopherol with sex steroid hormones and interactions with smoking: implications for prostate cancer risk
| Autor: | Sabine Rohrmann, William G. Nelson, Demetrius Albanes, Alison M. Mondul, Elizabeth A. Platz, Manning Feinleib, Andy Menke |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Male Vitamin Cancer Research medicine.medical_specialty medicine.medical_treatment alpha-Tocopherol Article Young Adult chemistry.chemical_compound Prostate cancer Sex hormone-binding globulin Risk Factors Sex Hormone-Binding Globulin Internal medicine medicine Humans Testosterone Tocopherol Young adult Gonadal Steroid Hormones biology business.industry Vitamin E Carcinoma Smoking Prostatic Neoplasms Middle Aged Nutrition Surveys medicine.disease respiratory tract diseases Cross-Sectional Studies Endocrinology Oncology chemistry behavior and behavior mechanisms biology.protein business |
| Zdroj: | Cancer Causes & Control. 22:827-836 |
| ISSN: | 1573-7225 0957-5243 |
| DOI: | 10.1007/s10552-011-9753-4 |
| Popis: | Vitamin E may protect against prostate cancer, possibly only in smokers and, we hypothesize, through altered sex steroid hormones. A controlled trial in smokers showed that sex hormone levels were inversely associated with baseline serum α-tocopherol and decreased in response to vitamin E supplementation. The vitamin E-hormone relation is understudied in non-smokers.Serum sex steroid hormones and α-tocopherol were measured for 1,457 men in NHANES III. Multivariable-adjusted geometric mean hormone concentrations by α-tocopherol quintile were estimated.We observed lower mean testosterone, estradiol, and SHBG concentrations with increasing serum α-tocopherol (Q1 = 5.5 and Q5 = 4.6 ng/ml, p-trend = 0.0007; Q1 = 37.8 and Q5 = 33.1 pg/ml, p-trend = 0.02; Q1 = 38.8 and Q5 = 30.6 pg/ml, p-trend = 0.05, respectively). Interactions between serum α-tocopherol and exposure to cigarette smoke for total testosterone, total estradiol, and SHBG were found with the inverse relation observed only among smokers.Results from this nationally representative, cross-sectional study indicate an inverse association between serum α-tocopherol and circulating testosterone, estradiol, and SHBG, but only in men who smoked. Our findings support vitamin E selectively influencing sex hormones in smokers and afford possible mechanisms through which vitamin E may impact prostate cancer risk. |
| Databáze: | OpenAIRE |
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