Maternal Plasma DHA Levels Increase Prior to 29 Days Post-LH Surge in Women Undergoing Frozen Embryo Transfer: A Prospective, Observational Study of Human Pregnancy
| Autor: | Dilys J. Freeman, Christopher C. Onyiaodike, Robert J. B. Nibbs, Scott M. Nelson, Heather Murray, Fiona Jordan, E. Ann Brown, Barbara J. Meyer, Helen Lyall, Naveed Sattar |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
0301 basic medicine medicine.medical_specialty Docosahexaenoic Acids Endocrinology Diabetes and Metabolism Clinical Biochemistry Context (language use) Biochemistry 03 medical and health sciences Endocrinology Pregnancy Internal medicine medicine Humans Prospective Studies Maternal-Fetal Exchange Twin Pregnancy chemistry.chemical_classification Fetus 030109 nutrition & dietetics business.industry Biochemistry (medical) Fatty acid Fasting Embryo Transfer medicine.disease Embryo transfer 030104 developmental biology chemistry Docosahexaenoic acid Pregnancy Twin Female business Hormone |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 101:1745-1753 |
| ISSN: | 1945-7197 0021-972X |
| DOI: | 10.1210/jc.2015-3089 |
| Popis: | Context: Docosahexaenoic acid (DHA) is an important fatty acid required for neurological development but its importance during early fetal neurological organogenesis is unknown. Objective: This study aimed to assess plasma fatty acid changes in early pregnancy in women undergoing natural cycle-frozen embryo transfer as a means of achieving accurately timed periconceptual sampling. Design: Women undergoing frozen embryo transfer were recruited and serial fasting blood samples were taken pre-luteinizing hormone (LH) surge, and at 18, 29, and 45 d post-LH surge and fatty acids were analyzed using gas chromatography. Setting: This study took place at the Assisted Conception Unit, Glasgow Royal Infirmary, Scotland. Main Outcome Measures: Plasma fatty acid concentrations and influence of twin pregnancies on DHA plasma concentration were measured. Results: In pregnant women, there was a rapid, early increase in the maternal rate of change of plasma DHA concentration observed by 29 d post-LH surge (mean ± SD, from 0.1 ± 1.3 to 1.6 ± 2.9 nmol DHA per mL plasma per day). This early pressure to increase plasma DHA concentration was further emphasized in twin pregnancies where the increase in DHA concentration over 45 d was 2-fold higher than in singleton pregnancies (mean ± SD increase, 74 ± 39 nmol/mL vs 36 ± 40 nmol/mL). An index of delta-6 desaturase activity increased 30% and positively correlated with the rate of change of DHA concentration between 18 and 29 d post-LH surge (R2 adjusted = 41%; P = .0002). DHA was the only fatty acid with a continual accelerated increase in plasma concentration and a positive incremental area under the curve (mean ± SD, 632 ± 911 nmol/mL × d) during the first 45 d of gestation. Conclusions: An increase in maternal plasma DHA concentration is initiated in human pregnancy prior to neural tube closure which occurs at 28 d gestation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|