The effects of natural nano-sized clinoptilolite and Nigella sativa supplementation on serum bone markers in diabetic rats
| Autor: | Elahe Bazri, Hossein Omidi, Mohammad Asghari-Jafarabadi, Ali Tarighat-Esfanjani, Mehran Mesgari Abbasi, Sirous Khorram, Yalda Salari Lak |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Medicine (General)
medicine.medical_specialty QH301-705.5 clinoptilolite Pharmaceutical Science chemistry.chemical_element 030209 endocrinology & metabolism Type 2 diabetes 030204 cardiovascular system & hematology Calcium General Biochemistry Genetics and Molecular Biology bone markers 03 medical and health sciences R5-920 0302 clinical medicine Insulin resistance Osteoprotegerin Internal medicine Diabetes mellitus diabetic medicine Vitamin D and neurology rat Biology (General) nigella sativa business.industry General Medicine medicine.disease Endocrinology chemistry Homeostatic model assessment Alkaline phosphatase business |
| Zdroj: | BioImpacts, Vol 9, Iss 3, Pp 173-178 (2019) |
| ISSN: | 2228-5652 2228-5660 |
| DOI: | 10.15171/bi.2019.21 |
| Popis: | Introduction: Many studies confirm that diabetes mellitus is associated with higher risks of bone fracture. The beneficial effects of Nigella sativa (NS) and clinoptilolite in preventing/reducing some diabetes-related disorders have been shown. This study was conducted to examine the effects of separate and concurrent supplementation of natural nano-sized clinoptilolite (NCLN) and NS on serum bone markers in rats with type 2 diabetes. Methods: A total of 42 (case=36 and control=6) adult male Wistar rats were divided into 2 groups: diabetic and non-diabetic. An oral glucose tolerance test and a homeostatic model assessment of insulin resistance (HOMA-IR) test were conducted to confirm diabetes. Then, the diabetic group was divided into 4 subgroups: [1] control (n=9), [2] NS 1%/food (n=9), [3] NCLN 2%/food (n=9), [4] NS 1%/food + NCLN 2%/food (n=9). After 7 weeks, serum levels of bone markers were determined using ELISA kits. Results: Analysis showed that serum levels of alkaline phosphatase (ALP) in the NCLN group (1318.6 ± 217.5 U/L) was significantly (P |
| Databáze: | OpenAIRE |
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