The association of maternal dietary folate intake and folic acid supplementation with small-for-gestational-age births: a cross-sectional study in Northwest China
| Autor: | Fangliang Lei, Hong Yan, Shanshan Li, Guoshuai Shi, Binyan Zhang, Xin Liu, Mengyao Xiao, Leqian Guo, Yue Cheng, Chao Li, Yezhou Liu, Minmin Li, Danmeng Liu, Shaonong Dang, Ruo Zhang, Zhonghai Zhu |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
China
medicine.medical_specialty Percentile Cross-sectional study Birth weight Medicine (miscellaneous) Standard score Folic Acid Pregnancy Interquartile range Surveys and Questionnaires medicine Humans Nutrition and Dietetics Obstetrics business.industry Confounding Infant Newborn Pregnancy Outcome medicine.disease Diet Cross-Sectional Studies Dietary Supplements Infant Small for Gestational Age Small for gestational age Female business |
| Zdroj: | British Journal of Nutrition. 122:459-467 |
| ISSN: | 1475-2662 0007-1145 |
| DOI: | 10.1017/s0007114519001272 |
| Popis: | The effect of maternal folate intake on small-for-gestational-age (SGA) births remains inconclusive. The present study aimed to investigate the associations of maternal folate intake from diet and supplements with the risk of SGA births using data from a cross-sectional study in Shaanxi Province of Northwest China. A total of 7307 women who were within 12 months (median 3; 10th–90th percentile 0–7) after delivery were included. Two-level models were adopted to examine the associations of folate (dietary folate, supplemental folic acid and total folate) intake with the risk of SGA births and birth weight Z score, controlling for a minimum set of confounders that were identified in a directed acyclic graph. Results showed that a higher supplemental folic acid intake during the first trimester was negatively associated with the risk of SGA births (≤60 d v. non-use: OR 0·80; 95 % CI 0·66, 0·96; >60 d v. non-use: OR 0·78; 95 % CI 0·65, 0·94; Ptrend = 0·010; per 10-d increase: OR 0·97; 95 % CI 0·95, 0·99). A higher total folate intake during pregnancy was associated with a reduced risk of SGA births (highest tertile v. lowest tertile: OR 0·77; 95 % CI 0·64, 0·94; Ptrend = 0·010; per one-unit increase in the log-transformed value: OR 0·81; 95 % CI 0·69, 0·95). A similar pattern was observed for the birth weight Z score. Our study suggested that folic acid supplementation during the first trimester and a higher total folate intake during pregnancy were associated with a reduced risk of SGA births. |
| Databáze: | OpenAIRE |
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