The long‐lasting love affair between the budding yeast Saccharomyces cerevisiae and the Epstein‐Barr virus
| Autor: | Cécile Voisset, Chrysoula Daskalogianni, Frédéric Bihel, Marc Blondel, Gaëlle Friocourt, María José Lista, Marie-Astrid Contesse, Robin Fåhraeus |
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| Rok vydání: | 2015 |
| Předmět: |
Epstein-Barr Virus Infections
Herpesvirus 4 Human Biomedical Research Saccharomyces cerevisiae Genome Viral Computational biology Biology medicine.disease_cause Applied Microbiology and Biotechnology Genome hemic and lymphatic diseases medicine Humans Models Immunological General Medicine biology.organism_classification Virology Epstein–Barr virus Budding yeast Yeast Review article Lytic cycle Host-Pathogen Interactions Molecular Medicine Biological Assay Oncovirus |
| Zdroj: | Biotechnology Journal. 10:1670-1681 |
| ISSN: | 1860-7314 1860-6768 |
| Popis: | The Epstein-Barr gammaherpesvirus (EBV) is the first oncogenic virus discovered in human. Indeed, EBV has been known for more than 50 years to be tightly associated with certain human cancers. As such, EBV has been the subject of extensive studies aiming at deciphering various aspects of its biological cycle, ranging from the regulation of its genome replication and maintenance to the induction of its lytic cycle, including the mechanisms that allow its immune evasion or that are related to its tumorogenicity. For more than 30 years the budding yeast Saccharomyces cerevisiae has fruitfully contributed to a number of these studies. The aim of this article is to review the various aspects of EBV biology for which yeast has been instrumental, and to propose new possible applications for these yeast-based assays, as well as the creation of further yeast models dedicated to EBV. This review article illustrates the tremendous potential of S. cerevisiae in integrated chemobiological approaches for the biomedical research. |
| Databáze: | OpenAIRE |
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