Coproduction of 16S rRNA Methyltransferase RmtD or RmtG with KPC-2 and CTX-M Group Extended-Spectrum β-Lactamases in Klebsiella pneumoniae

Autor:	Maria Fernanda Campagnari Bueno, Yohei Doi, Doroti de Oliveira Garcia, Gabriela R. Francisco, Jessica A. O'Hara
Rok vydání:	2013
Předmět:	Pharmacology Methyltransferase biology Klebsiella pneumoniae β lactamases Aminoglycoside resistance Klebsiella infections Drug resistance Ribosomal RNA biology.organism_classification 16S ribosomal RNA Microbiology Infectious Diseases Mechanisms of Resistance Pharmacology (medical)
Zdroj:	Antimicrobial Agents and Chemotherapy. 57:2397-2400
ISSN:	1098-6596 0066-4804
DOI:	10.1128/aac.02108-12
Popis:	Eight Klebsiella pneumoniae clinical strains with high-level aminoglycoside resistance were collected from eight hospitals in São Paulo State, Brazil, in 2010 and 2011. Three of them produced an RmtD group 16S rRNA methyltransferase, RmtD1 or RmtD2. Five strains were found to produce a novel 16S rRNA methyltransferase, designated RmtG, which shared 57 to 58% amino acid identity with RmtD1 and RmtD2. Seven strains coproduced KPC-2 with or without various CTX-M group extended-spectrum β-lactamases, while the remaining strain coproduced CTX-M-2.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3507e00433e5a6124095d76ebaedbab https://doi.org/10.1128/aac.02108-12 Zobrazit plný text záznamu