Salt-sensitive hypertension develops after transient induction of ANG II-dependent hypertension in Cyp1a1-Ren2 transgenic rats
| Autor: | K D Mitchell, John J. Mullins, Laura L. Howard, Matthew E. Patterson |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
medicine.medical_specialty
Hypertension Renal Indoles Physiology Urinary system Hemodynamics Blood Pressure Peptide hormone Antioxidants Renal Circulation Animals Genetically Modified Excretion Mice Internal medicine Renin Renin–angiotensin system Cytochrome P-450 CYP1A1 medicine Animals Transient (computer programming) Sodium Chloride Dietary Kidney Chemistry Angiotensin II Rats Disease Models Animal medicine.anatomical_structure Endocrinology Glomerular Filtration Rate |
| Zdroj: | American Journal of Physiology-Renal Physiology. 288:F810-F815 |
| ISSN: | 1522-1466 1931-857X |
| DOI: | 10.1152/ajprenal.00148.2004 |
| Popis: | Transient exposure to ANG II results in the development of salt-sensitive hypertension in rats. This study was performed to determine whether a transient hypertensive episode can induce salt-sensitive hypertension in transgenic rats with inducible expression of the mouse Ren2 renin gene [strain name TGR(Cyp1a1-Ren2)]. Systolic blood pressures were measured in conscious male Cyp1a1-Ren2 rats ( n = 6) during control conditions and during dietary administration of indole-3-carbinol (I3C; 0.15%, wt/wt), for 14 days. Systolic pressure increased from 135 ± 5 to 233 ± 7 mmHg by day 14. I3C administration was terminated and blood pressure returned to normal levels (137 ± 5 mmHg) within 10 days. Subsequently, the rats were placed on a high-salt diet (8% NaCl) for 10 days. Systolic pressure increased by 34 ± 2 mmHg throughout 10 days of the high-salt diet. Neither glomerular filtration rate nor renal plasma flow was altered in Cyp1a1-Ren2 rats with salt-sensitive hypertension. In a separate group of male Cyp1a1-Ren2 rats ( n = 6) transiently induced with 0.15% I3C for 14 days, administration of the superoxide dismutase mimetic tempol (4-hydroxy-2,2,6,6-tetramethyl piperidinoxyl, 2 mM) attenuated the increase in systolic pressure induced by high salt. Systolic pressure increased by only 11 ± 1 mmHg throughout 8 days of a high-salt diet and tempol administration. Thus transient induction of ANG II-dependent hypertension via activation of the Cyp1a1-Ren2 transgene induces salt-sensitive hypertension in these transgenic rats. The attenuation by tempol of the high salt-induced blood pressure elevation indicates that ANG II-induced production of superoxide anion contributes to the development of salt-sensitive hypertension after transient induction of ANG II-dependent hypertension. |
| Databáze: | OpenAIRE |
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