Structure and Dynamics of Alginate Gels Cross-Linked by Polyvalent Ions Probed via Solid State NMR Spectroscopy
| Autor: | Rafał Konefał, Jiri Brus, David Vetchy, Pavel Kulich, Martina Urbanova, Jirí Horský, Katerina Kubova, Jakub Vyslouzil, Jan Vysloužil, Jiri Czernek, Miroslava Pavelková, Sabina Abbrent |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Magnetic Resonance Spectroscopy
Calcium alginate Polymers and Plastics Alginates Bioengineering 02 engineering and technology 010402 general chemistry 01 natural sciences Homogeneous distribution Biomaterials chemistry.chemical_compound Glucuronic Acid Polymer chemistry Materials Chemistry Molecule chemistry.chemical_classification Ion exchange Hexuronic Acids Biomaterial Hydrogels Microbead (research) Polymer 021001 nanoscience & nanotechnology 3. Good health 0104 chemical sciences Cross-Linking Reagents Solid-state nuclear magnetic resonance chemistry 0210 nano-technology |
| Zdroj: | Biomacromolecules. 18:2478-2488 |
| ISSN: | 1526-4602 1525-7797 |
| Popis: | Alginate gels are an outstanding biomaterial widely applicable in tissue engineering, medicine, and pharmacy for cell transplantation, wound healing and efficient bioactive agent delivery, respectively. This contribution provides new and comprehensive insight into the atomic-resolution structure and dynamics of polyvalent ion-cross-linked alginate gels in microbead formulations. By applying various advanced solid-state NMR (ssNMR) spectroscopy techniques, we verified the homogeneous distribution of the cross-linking ions in the alginate gels and the high degree of ion exchange. We also established that the two-component character of the alginate gels arises from the concentration fluctuations of residual water molecules that are preferentially localized along polymer chains containing abundant mannuronic acid (M) residues. These hydrated M-rich blocks tend to self-aggregate into subnanometer domains. The resulting coexistence of two types of alginate chains differing in segmental dynamics was revealed by ... |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|