Clinical issues surrounding once-daily aminoglycoside dosing in children
| Autor: | Chad A. Knoderer, Julie A. Everett, William F. Buss |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
medicine.medical_specialty
Adolescent medicine.drug_class Antibiotics medicine Humans Pharmacology (medical) Dosing Intensive care medicine Child Antibacterial agent Randomized Controlled Trials as Topic business.industry Aminoglycoside Infant medicine.disease Anti-Bacterial Agents Aminoglycosides Treatment Outcome El Niño Child Preschool Once daily business Gram-Negative Bacterial Infections Kidney disease Pediatric population Half-Life |
| Zdroj: | Pharmacotherapy. 23(1) |
| ISSN: | 0277-0008 |
| Popis: | Aminoglycoside antibiotics are first-line treatment for many infectious diseases in the pediatric population and are effective in adults. The traditional dosing interval in children is every 8-12 hours. Studies in adults reported equivalent efficacy and equal or less toxicity with once-daily regimens. Despite many studies in the adult population, this approach has yet to become standard practice in most pediatric hospitals. Reasons for lack of acceptance of this strategy in children include rapid aminoglycoside clearance, unknown duration of postantibiotic effect, safety concerns, and limited clinical and efficacy data. |
| Databáze: | OpenAIRE |
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