Asymmetric Conjugate Addition of α-Cyanoketones to Enones Using Diaminomethylenemalononitrile Organocatalyst

Autor:	Yuta Noda, Kosuke Nakashima, Shin-ichi Hirashima, Yuji Koseki, Tsuyoshi Miura
Rok vydání:	2018
Předmět:	010405 organic chemistry Chemistry Organic Chemistry 010402 general chemistry 01 natural sciences Combinatorial chemistry 0104 chemical sciences Conjugate Catalysis Stereocenter
Zdroj:	The Journal of Organic Chemistry. 83:2402-2408
ISSN:	1520-6904 0022-3263
Popis:	A diaminomethylenemalononitrile organocatalyst efficiently catalyzed the asymmetric conjugate addition of α-cyanoketones to vinyl ketones to give the corresponding 1,5-dicarbonyl compounds, which bear an all-carbon quaternary stereogenic center with high enantioselectivities. This report is the first example of the asymmetric conjugate addition of α-cyanoketones to vinyl ketones using an organocatalyst.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c34bd383a0f0e3e51aea2319b93a6094 https://doi.org/10.1021/acs.joc.7b02976 Zobrazit plný text záznamu