Hybrid cholesterol-based nanocarriers containing phosphorescent Ir complexes: In vitro imaging on glioblastoma cell line
| Autor: | Maria Naddaka, Mario Chiariello, Letizia Sambri, Federica Sasdelli, Elia Matteucci, Paolo Zani, Mauro Comes Franchini, David Colecchia, Andrea Baschieri, Erica Locatelli, Ilaria Monaco |
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| Přispěvatelé: | Naddaka, Maria, Locatelli, Erica, Colecchia, David, Sambri, Letizia, Monaco, Ilaria, Baschieri, Andrea, Sasdelli, Federica, Chiariello, Mario, Matteucci, Elia, Zani, Paolo, Comes Franchini, Mauro, DIPARTIMENTO DI CHIMICA 'GIACOMO CIAMICIAN', DIPARTIMENTO DI CHIMICA INDUSTRIALE 'TOSO MONTANARI', Facolta' di CHIMICA INDUSTRIALE |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
chemistry.chemical_classification
hybrid inorganic-organic nanoparticles General Chemical Engineering hybrid inorganic-organic nanoparticles cholesterol phosphorescent cancer glioblastoma glioblastoma cholesterol Nanotechnology Peptide General Chemistry Fluorescence Combinatorial chemistry chemistry.chemical_compound Chlorotoxin chemistry Covalent bond PEG ratio Copolymer cancer Nanocarriers Phosphorescence phosphorescent |
| Popis: | none 11 no Recently the use of phosphorescent heavy-metal complexes in bioimaging techniques has been a promising research field and has been attracted increasing interest. Among these, phosphorescent iridium(III) complexes have shown many photophysical characteristics that made them promising candidates for fluorescence probes. In this study an innovative copolymer consisting of cholesterol, a natural component of biological membranes, and the well-known biocompatible Polyethylene (PEG), has been synthesized. Cholesterol–PEG amphiphilic copolymer has been used to formnovel nanocarriers characterized by the incorporation and/or linkage of the phosphorescent iridium(III) derivatives through covalent or non-covalent interactions. Finally the nanocarrier's surface has been functionalized with the peptide chlorotoxin (Cltx), a targeting agent selective for glioblastoma cells (U87MG). The so obtained targeted water soluble nanocarrier has been tested for in vitro imaging on the glioblastoma cell line and has shown no toxic effect on cells. Naddaka, Maria; Locatelli, Erica; Colecchia, David; Sambri, Letizia; Monaco, Ilaria; Baschieri, Andrea; Sasdelli, Federica; Chiariello, Mario; Matteucci, Elia; Zani, Paolo; Comes Franchini, Mauro Naddaka, Maria; Locatelli, Erica; Colecchia, David; Sambri, Letizia; Monaco, Ilaria; Baschieri, Andrea; Sasdelli, Federica; Chiariello, Mario; Matteucci, Elia; Zani, Paolo; Comes Franchini, Mauro |
| Databáze: | OpenAIRE |
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