Transcranial Magnetic Stimulation for Obsessive-Compulsive Disorder: An Updated Systematic Review and Meta-analysis
| Autor: | Perminder S. Sachdev, Isa Albuquerque Sato, Caio Barbosa Kaku, Pedro Shiozawa, Alisson Paulino Trevizol, Fernanda Bs. Guimarães, Sujit Sarkhel, Ian A. Cook, Quirino Cordeiro |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male medicine.medical_specialty Obsessive-Compulsive Disorder genetic structures medicine.medical_treatment Neuroscience (miscellaneous) Stimulation behavioral disciplines and activities law.invention 03 medical and health sciences Young Adult 0302 clinical medicine Electroconvulsive therapy Physical medicine and rehabilitation Randomized controlled trial law Intervention (counseling) mental disorders Medicine Humans Young adult Electroconvulsive Therapy business.industry Middle Aged equipment and supplies Transcranial Magnetic Stimulation 030227 psychiatry Transcranial magnetic stimulation Psychiatry and Mental health Brain stimulation Meta-analysis Female business human activities 030217 neurology & neurosurgery |
| Zdroj: | The journal of ECT. 32(4) |
| ISSN: | 1533-4112 |
| Popis: | Transcranial magnetic stimulation (TMS) is a promising noninvasive brain stimulation intervention. Transcranial magnetic stimulation has been proposed for obsessive-compulsive disorder (OCD) with auspicious results.To assess the efficacy of TMS for OCD in randomized clinical trials (RCTs).Systematic review using MEDLINE and EMBASE from the first RCT available until March 11, 2016. The main outcome was the Hedges g for continuous scores for Yale-Brown Obsessive Compulsive Scale in a random-effects model. Heterogeneity was evaluated with the I and the χ test. Publication bias was evaluated using the Begg funnel plot. Metaregression was performed using the random-effects model modified by Knapp and Hartung.We included 15 RCTs (n = 483), most had small-to-modest sample sizes. Comparing active versus sham TMS, active stimulation was significantly superior for OCD symptoms (Hedges g = 0.45; 95% confidence interval, 0.2-0.71). The funnel plot showed that the risk of publication bias was low and between-study heterogeneity was low (I = 43%, P = 0.039 for the χ test). Metaregression showed no particular influence of any variable on the results.Transcranial magnetic stimulation active was superior to sham stimulation for the amelioration of OCD symptoms. Trials had moderate heterogeneity results, despite different protocols of stimulation used. Further RCTs with larger sample sizes are fundamentally needed to clarify the precise impact of TMS in OCD symptoms. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|