Estimation of alveolar deposition ratio of inhaled radioaerosol
| Autor: | Akio Ebina, Takeo Teshima, Tomio Hirano, Toyoharu Isawa, Kiyoshi Konno |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
Lung Diseases
Male Airway clearance Continuous measurement Mucociliary clearance General Biochemistry Genetics and Molecular Biology Smoking history Forced Expiratory Volume medicine Humans Deposition (phase transition) Radionuclide Imaging Technetium Tc 99m Aggregated Albumin Aged Aerosols Lung Inhalation business.industry Chemistry Cineradiography General Medicine Middle Aged respiratory system Respiratory Function Tests respiratory tract diseases medicine.anatomical_structure Anesthesia Regression Analysis Female Nuclear medicine business Airway |
| Zdroj: | The Tohoku Journal of Experimental Medicine. 145:259-267 |
| ISSN: | 1349-3329 0040-8727 |
| DOI: | 10.1620/tjem.145.259 |
| Popis: | The lung retention ratio (LRR) and the alveolar deposition ratio (ALDR) are mandatory to calculate the other three indices for quantitatively evaluating mucociliary clearance function of the ciliated airways; the airway deposition ratio (ADR), the airway retention ratio (ARR) and the airway clearance efficiency (ACE). According to our original method, the LRR required 2-hr continuous measurement of radioactivity in the thorax and the ALDR a repeat measurement at 24-hr after radioaerosol inhalation. The 2-hr continuous measurement is, however, too long for a clinical examination and the 24-hr repeat measurement cumbersome. The purpose of the study was to find a way to get the ALDR by calculation without repeating the 24-hr measurement and by counting radioactivity for the shortest possible period and yet without sacrificing the visual evaluation by compiling radioaerosol inhalation lung cine-scintigraphy. By using the derived formulae listed in Table 1, the ALDR was calculable. Forced expiratory volume (FEV) in one sec divided by FEV in per cent (FEV1.0%), the initial 60 min measurement of radioactivity without repeating 24-hr measurement, and smoking history were the minimum requirements to calculate the ALDR. The calculated ALDR appeared reliable enough to estimate the other indices. |
| Databáze: | OpenAIRE |
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