Mechanisms of neonatal mucosal antibody protection
| Autor: | Harris, N. L., Spoerri, I., Schopfer, J. F., Nembrini, C., Merky, P., Massacand, J., Joseph Urban, Lamarre, A., Burki, K., Odermatt, B., Zinkernagel, R. M., Macpherson, A. J. |
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| Přispěvatelé: | University of Zurich, Harris, N L |
| Rok vydání: | 2006 |
| Předmět: |
2403 Immunology
Immunity Maternally-Acquired/*immunology Receptors Fc/metabolism Bacterial Infections/immunology/prevention & control 610 Medicine & health Milk/*immunology Immunoglobulin G/blood/*immunology Nematospiroides dubius/immunology Histocompatibility Antigens Class I/metabolism Intestinal Mucosa/*immunology/microbiology/parasitology Mice Inbred C57BL Mice Animals Newborn 2723 Immunology and Allergy Animals 570 Life sciences biology Antibodies/immunology Female 10239 Institute of Laboratory Animal Science Immunity Mucosal Immunoglobulin A Secretory/*immunology Strongylida Infections/immunology/prevention & control |
| Zdroj: | Scopus-Elsevier |
| DOI: | 10.5167/uzh-10880 |
| Popis: | Following an abrupt transition at birth from the sterile uterus to an environment with abundant commensal and pathogenic microbes, neonatal mammals are protected by maternal Abs at mucosal surfaces. We show in mice that different Ab isotypes work in distinct ways to protect the neonatal mucosal surface. Secretory IgA acts to limit penetration of commensal intestinal bacteria through the neonatal intestinal epithelium: an apparently primitive process that does not require diversification of the primary natural Ab repertoire. In contrast, neonatal protection against the exclusively luminal parasite Heligmosomoides polygyrus required IgG from primed females. This immune IgG could either be delivered directly in milk or retrotransported via neonatal Fc receptor from the neonatal serum into the intestinal lumen to exert its protective effect. |
| Databáze: | OpenAIRE |
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