Intralesional vitamin D3 versus new topical photodynamic therapy in recalcitrant palmoplanter warts Randomized comparative controlled study
| Autor: | Maha Fadel, Ahmed Sadek, Abeer Attia Tawfik, Nahla A. Ibrahim, Doaa A. Abdel Fadeel |
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| Rok vydání: | 2020 |
| Předmět: |
Vitamin
medicine.medical_specialty medicine.medical_treatment 030303 biophysics Biophysics Photodynamic therapy Dermatology Group B 030207 dermatology & venereal diseases 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine Humans Pharmacology (medical) Prospective Studies Cholecalciferol 0303 health sciences Photosensitizing Agents business.industry Immunotherapy Viral warts Oncology chemistry Photochemotherapy Warts business |
| Zdroj: | Photodiagnosis and photodynamic therapy. 32 |
| ISSN: | 1873-1597 |
| Popis: | Background Recalcitrant palmoplanter warts represent a therapeutic challenge. Side effects of local destructive methods necessitates the need for other less morbid modalities. Recently immunotherapy as well as light based devices and lasers have emerged as therapeutic approaches. Aim of the study To compare between the safety and efficacy of intralesional vitamin D3 injection and photodynamic therapy (PDT) using eosin in treatment of recalcitrant palmoplanter warts. Patients and Methods Prospective, randomized, controlled comparative study. Fifty -six patients with recalcitrant palmoplanter warts were randomly divided into 3 groups. Group A was injected with intralesional vitamin D3. Group B was subjected to PDT using eosin loaded in trasferosomes as a photosensitizer. Group C is the control group. Clinical improvement was assessed by photographic records and dermoscopic assessment, at baseline, before each session and after completion of treatment. Patients were followed up for 6 months after cure to detect recurrence. Results Group A and B showed complete clearance in 88.89 % and 86.36 % respectively compared to 18.75 % in the control group. These results were statistically significant (P value Conclusion In the current study, both vitamin D3 and PDT using Eosin are safe, highly effective and well tolerated modalities in treatment of viral warts |
| Databáze: | OpenAIRE |
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