Toxicokinetic of tris(2-butoxyethyl) phosphate (TBOEP) in humans following single oral administration
| Autor: | Veronika Fuchs, Wolfgang Völkel, Mandy Wöckner, Hermann Fromme |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Tris Adult Male Health Toxicology and Mutagenesis Administration Oral Urine 010501 environmental sciences Toxicology 01 natural sciences 03 medical and health sciences chemistry.chemical_compound Organophosphorus Compounds Oral administration Plasticizers Germany Biomonitoring Toxicity Tests Ethylamines Toxicokinetics Humans Child 0105 earth and related environmental sciences Flame Retardants Tris(2-butoxyethyl) phosphate Reference dose Chromatography Infant Dust General Medicine Middle Aged Phosphate Organophosphates 030104 developmental biology chemistry Environmental chemistry Child Preschool Female Biomarkers |
| Zdroj: | Archives of toxicology. 92(2) |
| ISSN: | 1432-0738 |
| Popis: | Tris(2-butoxyethyl) phosphate (TBOEP; 20 µg/kg b.w.) was orally administered to three female and three male volunteers. In urine samples collected for 39 h three metabolites of TBOEP were quantitated. bis(2-butoxyethyl) phosphate (BBOEP), tris(2-(3-hydroxy)butoxyethyl) phosphate (OH-TBOEP), bis(2-butoxyethyl)-(2-hydroxyethyl) phosphate (BBOEHEP) were observed in all urine samples within the first 7 h with highest concentration for BBOEHEP. C max of OH-TBOEP was in the range of 2–4 h and t 1/2 was between 1.5 and 6.1 h. Similar results were obtained for BBOEHEP. In contrast BBOEP showed several maxima within 25 h and, therefore, no toxicokinetic data were calculated. As proof of concept 54 urine samples of children staying at day-care centers in Germany were analysed for all 3 biomarkers. Only BBOEP and BBOEHEP were detected in about 80% of the samples with a median of 0.16 µg/l for BBOEP and 0.18 µg/l for BBOEHEP. A recalculation of daily intake (DI) based on BBOEHEP resulted in a clear undercut of the current reference dose of 50 µg/kg per day. As observed in other studies a calculation of the DI based on the dust concentrations and oral uptake of 20 mg of dust for 8 h for young children results in considerably higher DI but would also not exceed the RfD. |
| Databáze: | OpenAIRE |
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