Treatment effects of Ginkgo biloba extract EGb 761® on the spectrum of behavioral and psychological symptoms of dementia: meta-analysis of randomized controlled trials
| Autor: | Serge Gauthier, Heiko Mueller, Armin von Gunten, Egemen Savaskan, Robert Hoerr |
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| Přispěvatelé: | University of Zurich, Hoerr, Robert |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty 610 Medicine & health 2717 Geriatrics and Gerontology Behavioral Symptoms Placebo Euphoriant law.invention 2738 Psychiatry and Mental Health 03 medical and health sciences Cognition 0302 clinical medicine Randomized controlled trial Quality of life law Internal medicine Humans Medicine Dementia Vascular dementia Aged Randomized Controlled Trials as Topic Psychiatric Status Rating Scales Behavioral Symptoms/complications Behavioral Symptoms/drug therapy Cognition/drug effects Dementia/complications Dementia/drug therapy Ginkgo biloba/chemistry Mental Disorders/complications Mental Disorders/drug therapy Middle Aged Phytotherapy/methods Plant Extracts/administration & dosage Plant Extracts/adverse effects Plant Extracts/therapeutic use Quality of Life Treatment Outcome BPSD EGb 761® Ginkgo biloba behavioral and psychological symptoms dementia meta-analysis systematic review 030214 geriatrics biology Plant Extracts business.industry Mental Disorders 3203 Clinical Psychology 11359 Institute for Regenerative Medicine (IREM) 2909 Gerontology medicine.disease biology.organism_classification Psychiatry and Mental health Clinical Psychology Meta-analysis Geriatrics and Gerontology business Gerontology 030217 neurology & neurosurgery Phytotherapy |
| Zdroj: | International psychogeriatrics, vol. 30, no. 3, pp. 285-293 Europe PubMed Central |
| Popis: | Background:In randomized controlled trials, Ginkgo biloba extract EGb 761® has been found to be effective in the treatment of behavioral and psychological symptoms of dementia (BPSD).Methods:To assess the effects of EGb 761® on specific BPSD, we analyzed data from all randomized, placebo-controlled, at least 20-week, trials of EGb 761® enrolling patients with dementia (probable Alzheimer's disease (AD), probable vascular dementia or probable AD with cerebrovascular disease) who had clinically significant BPSD (Neuropsychiatric Inventory (NPI) total score at least 6). Data were pooled and joint analyses of NPI single item composite and caregiver distress scores were performed by meta-analysis with a fixed effects model.Results:Four trials involving 1628 patients (EGb 761®, 814; placebo, 814) were identified; treatment duration was 22 or 24 weeks; the daily dose of EGb 761® was 240 mg in all trials. Pooled analyses including data from the full analysis sets of all trials (EGb 761®, 796 patients; placebo, 802 patients) revealed significant superiority of EGb 761® over placebo in total scores and 10 single symptom scores. Regarding caregiver distress scores, EGb 761®-treated patients improved significantly more than those receiving placebo in all symptoms except delusions, hallucinations, and elation/euphoria. The benefit of EGb 761® mainly consists of improvement in symptoms present at baseline, but the incidence of some symptoms was also decreased.Conclusions:Twenty two- to twenty four-week treatment with Ginkgo biloba extract EGb 761® improved BPSD (except psychotic-like features) and caregiver distress caused by such symptoms. |
| Databáze: | OpenAIRE |
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