Continuous‐Flow Pd‐Catalyzed Carbonylation of Aryl Chlorides with Carbon Monoxide at Elevated Temperature and Pressure
| Autor: | Luc Moens, C. Oliver Kappe, Alejandro Mata, Christopher A. Hone, Bernhard Gutmann |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
gas-liquid transformation
Halide carbonylation 010402 general chemistry 01 natural sciences Catalysis carbon monoxide (hetero)aryl chlorides Inorganic Chemistry chemistry.chemical_compound continuous flow Reactivity (chemistry) Physical and Theoretical Chemistry 010405 organic chemistry Aryl Communication Organic Chemistry Combinatorial chemistry Communications 0104 chemical sciences Pd-catalyzed Temperature and pressure chemistry Methanol Carbonylation Carbon monoxide |
| Zdroj: | Chemcatchem |
| ISSN: | 1867-3899 1867-3880 |
| Popis: | The development of a continuous‐flow protocol for a palladium‐catalyzed methoxycarbonylation of (hetero)aryl chlorides using carbon monoxide gas and methanol is described. (Hetero)aryl chlorides are the least expensive of the aryl halides, but are underutilized in carbonylation reactions due to their very poor reactivity. The described protocol exploits intensified conditions at elevated temperature and pressure, which are readily accessed within a continuous‐flow environment, to provide moderate to excellent product yields (11 examples) in a short 16 min residence time. The continuous‐flow protocol enables the safe and potentially scalable carbonylation of aryl chlorides using CO gas. Continuous‐flow Pd‐catalyzed carbonylation of aryl chlorides with carbon monoxide at elevated temperature and pressure @KappeLab @RCPE @UniGraz @JanssenGlobal |
| Databáze: | OpenAIRE |
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