Predictive value of serum interleukin-6 level in influenza virus-associated encephalopathy
| Autor: | Mika Mochizuki, Mitsuaki Kimura, Hiroatsu Hojo, Hideo Aiba |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Male
Time Factors Encephalopathy Orthomyxoviridae medicine.disease_cause Virus Central nervous system disease Predictive Value of Tests Influenza Human medicine Influenza A virus Humans Interferon gamma Interleukin 6 Child Brain Diseases biology business.industry Interleukin-6 Infant medicine.disease biology.organism_classification Prognosis Child Preschool Immunology biology.protein Cytokines Female Neurology (clinical) Complication business medicine.drug |
| Zdroj: | Neurology. 57(2) |
| ISSN: | 0028-3878 |
| Popis: | In Japan,200 children with influenza virus-associated encephalopathy were reported in 1999 and the mortality rate was high. The levels of tumor necrosis factor-alpha (TNFalpha) and interleukin-6 (IL-6) in both CSF and serum were significantly increased in severe cases. The authors found a correlation between elevated serum cytokine levels and mortality and neurologic morbidity.TNFalpha, IL-6, soluble tumor necrosis factor receptor 1 (sTNF-R1), interferon-gamma (IFNgamma), and IL-2 were measured by the ELISA method in sera from six children with encephalopathy before and during therapy, and in six age-matched controls with influenza type A virus infection.The increases in the serum TNFalpha, IL-6, and sTNF-R1 levels were statistically significant at the onset of symptoms before therapy, but the IL-6 level was most useful for diagnosis. The serum IL-6 levels were6,000 pg/mL in children with brain stem dysfunction, about 150 pg/mL in children without brain stem dysfunction, and80 pg/mL in controls. The time course of the serum IL-6 level also reflected the clinical condition. Once the serum IL-6 level was increased to15,000 pg/mL, none of the children survived. The lower the maximal serum IL-6 level, the milder the CNS sequelae.The serum IL-6 level may be the most useful indicator for the diagnosis and the clinical severity of influenza virus-associated encephalopathy. |
| Databáze: | OpenAIRE |
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