Growth in Sotos syndrome
| Autor: | David Ravine, T R P Cole, N J Shaw, J C Agwu, J Kirk, S Chapman |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Adult
Male Pediatrics medicine.medical_specialty Adolescent Population Growth Gigantism Age Determination by Skeleton Acromegaly medicine Humans education Child Menarche education.field_of_study Anthropometry Sotos syndrome business.industry Facies Bone age Syndrome Original Articles medicine.disease Prognosis Body Height Surgery El Niño Child Preschool Pediatrics Perinatology and Child Health Female business |
| Zdroj: | Archives of disease in childhood. 80(4) |
| ISSN: | 1468-2044 |
| Popis: | Although there are several reports on infant and childhood growth in patients with Sotos syndrome, there is little information on the final height achieved and puberty. Growth data on 40 patients (20 female and 20 male) aged 2-31 years were collected. These showed that patients with Sotos syndrome are excessively tall at birth, during infancy, and during childhood. Disproportionately long limbs constitute much of the increase in stature. However, the combination of advanced bone age and early onset of menarche led to a mean (SD) final height of 172.9 (5.7) cm in women. This is within the normal range for the population. Most of the men also attained a final height (mean, 184.3 cm; SD, 6.0) within the normal range, although exceptions were more likely in men than in women. Therefore, these results show that most patients with Sotos syndrome do not require intervention to limit their adult height. |
| Databáze: | OpenAIRE |
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