In vitro digestion of starches in a dynamic gastrointestinal model: an innovative study to optimize dietary management of patients with hepatic glycogen storage diseases
| Autor: | Terry G J Derks, Ingrid Dalira Schweigert Perry, Mario T. R. van Wandelen, G. Peter A. Smit, Tatiéle Nalin, David A. Weinstein, Koen Venema, Carolina Fischinger Moura de Souza, Margreet van Rijn, Ida Vanessa Doederlein Schwartz |
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| Přispěvatelé: | Humane Biologie, RS: NUTRIM - R1 - Metabolic Syndrome, RS: NUTRIM - HB/BW section A, Center for Liver, Digestive and Metabolic Diseases (CLDM) |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Starch
DIGESTIBILITY Carbohydrate metabolism Glycogen Storage Disease Type I HEALTHY-MEN Models Biological THERAPY Modified starch GLUCOSE chemistry.chemical_compound INTESTINE Genetics medicine Humans Food science Genetics (clinical) Glycemic GLYCEMIC RESPONSE IA Stomach CLINICAL COURSE food and beverages Starch analysis Small intestine PRODUCTS medicine.anatomical_structure chemistry UNCOOKED CORNSTARCH Digestion |
| Zdroj: | Journal of Inherited Metabolic Disease, 38(3), 529-536. Wiley Journal of Inherited Metabolic Disease, 38(3), 529-536. SPRINGER |
| ISSN: | 0141-8955 |
| DOI: | 10.1007/s10545-014-9763-y |
| Popis: | Uncooked cornstarch (UCCS) is a widely used treatment strategy for patients with hepatic glycogen storage disease (GSD). It has been observed that GSD-patients display different metabolic responses to different cornstarches. The objective was to characterize starch fractions and analyze the digestion of different starches in a dynamic gastrointestinal in vitro model. The following brands of UCCS were studied: Argo (R) and Great Value (R) from the United States of America; Brazilian Maizena Duryea (R) and Yoki (R) from Brazil; Dutch Maizena Duryea (R) from the Netherlands. Glycosade (R), a modified starch, and sweet polvilho, a Brazilian starch extracted from cassava, were also studied. The starch fractions were analyzed by glycemic TNO index method and digestion analyses were determined by the TIM-1 system, a dynamic, computer-controlled, in vitro gastrointestinal model, which simulates the stomach and small intestine. The final digested amounts were between 84 and 86 % for the UCCS and Glycosade (R), but was 75.5 % for sweet povilho. At 180 min of the experiment, an important time-point for GSD patients, the digested amount of the starches corresponded to 67.9-71.5 for the UCCS and Glycosade (R), while it was 55.5 % for sweet povilho. In an experiment with a mixture of sweet polvilho and Brazilian Maizena Duryea (R), a final digested amount of 78.4 % was found, while the value at 180 min was 61.7 %. Sweet polvilho seems to have a slower and extended release of glucose and looks like an interesting product to be further studied as it might lead to extended normoglycemia in GSD-patients. |
| Databáze: | OpenAIRE |
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