Endocrine effects of testosterone undecanoate as a supplementary treatment to menopausal gonadotropins or tamoxifen citrate in idiopathic oligozoospermia
| Autor: | Leonidas Kontogeorgos, Maria Karamertzanis, Stamatina Nicopoulou, Panayiotis Vassilopoulos, Dimitrios A. Adamopoulos, Niki Kapolla |
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| Rok vydání: | 1995 |
| Předmět: |
Adult
Male endocrine system medicine.medical_specialty Menotropins medicine.drug_class Chorionic Gonadotropin Andrology Gonadotropin-Releasing Hormone Basal (phylogenetics) stomatognathic system Internal medicine Testis medicine Humans Testosterone skin and connective tissue diseases Thyrotropin-Releasing Hormone Leydig cell Sperm Count business.industry Obstetrics and Gynecology Leydig Cells Oligospermia Luteinizing Hormone Androgen Antiestrogen medicine.disease Prolactin Tamoxifen medicine.anatomical_structure Endocrinology Reproductive Medicine Pituitary Gland Drug Therapy Combination Gonadotropin Follicle Stimulating Hormone business hormones hormone substitutes and hormone antagonists Hormone |
| Zdroj: | Fertility and sterility. 64(4) |
| ISSN: | 0015-0282 |
| Popis: | Objective To evaluate the effects of T undecanoate given as a supplementary treatment with tamoxifen citrate (TAM) or hMG on pituitary and Leydig cell function in men with idiopathic oligozoospermia. Design A total of 48 normogonadotropic men with idiopathic oligozoospermia were allocated in to six groups (n=8 per group) treated with placebo, 40mgT undecanoate three times per day, 10mg TAM two times per day, T undecanoate and TAM, 75IU/d hMG, and T undecanoate and hMG. All groups were evaluated with standard GnRH, thyrotropin-releasing hormone, and hCG tests before and on the final day of 3months on treatment with measurements of FSH, LH, thyroid-stimulating hormone (TSH), PRL, T, E 2 , 17-hydroxyprogesterone, sex hormone-binding globulin, and seminal analyses (at least twice each time). Results Basal and stimulated concentrations and incremental FSH and LH values showed no differences among TAM or hMG and TAM+T undecanoate or hMG+T undecanoate treated groups. Basal, stimulated, and incremental values for TSH and PRL were elevated markedly during treatment in most groups in comparison to placebo. Basal, stimulated, and incremental T and E 2 values were similar in active treatment groups except that higher T concentration was found in TAM+T undecanoate as compared with T undecanoate only treated men. Finally, significant improvements were noted in important seminal parameters and particularly in the functional sperm fraction of the TAM+T undecanoate group as compared with single treatment with TAM. Conclusion These results indicate that T undecanoate in combination with TAM or hMG not only had no adverse effects on pituitary and Leydig cell activity but also seemed to improve important seminal parameters and signify that androgens may be tried as a supplementary treatment to conventional regimes in idiopathic oligozoospermia. |
| Databáze: | OpenAIRE |
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