A peptidic hydrogel that may behave as a 'Trojan Horse'
| Autor: | Claudia Tomasini, Giuseppe Falini, Giorgio Sartor, Natalia Calonghi, Carola Eleonora Parolin, Nicola Castellucci |
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| Přispěvatelé: | N. Castellucci, G. Sartor, N. Calonghi, C. Parolin, G. Falini, C. Tomasini |
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Azelaic acid
media_common.quotation_subject confocal microscopy Full Research Paper law.invention lcsh:QD241-441 lcsh:Organic chemistry Confocal microscopy law medicine Moiety Organic chemistry Internalization lcsh:Science media_common chemistry.chemical_classification FLUORESCENCE MODULATION amino acids Organic Chemistry Fatty acid low molecular weight hydrogelator Fluorescence Combinatorial chemistry Amino acid Chemistry chemistry Self-healing hydrogels PSEUDOPEPTIDES lcsh:Q hydrogel controlled release medicine.drug |
| Zdroj: | Beilstein Journal of Organic Chemistry, Vol 9, Iss 1, Pp 417-424 (2013) Beilstein Journal of Organic Chemistry 'Beilstein Journal of Organic Chemistry ', vol: 9, pages: 417-424 (2013) |
| ISSN: | 1860-5397 |
| Popis: | A physical hydrogel prepared with the low-molecular-weight hydrogelator (LMWHG) CH2(C3H6CO-L-Phe-D-Oxd-OH)2 and water/ethanol mixture was applied as a potential “Trojan Horse” carrier into cells. By SEM and XRD analysis we could demonstrate that a fibrous structure is present in the xerogel, making a complex network. The gelator is derived from α-amino acids (Thr, Phe) and a fatty acid (azelaic acid) and is biocompatible: it was dosed to IGROV-1 cells, which internalized it, without significantly affecting the cell proliferation. To check the internalization process by confocal microscopy, fluorescent hydrogels were prepared, introducing the fluorescent dansyl moiety into the mixture. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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