Synthesis and cytotoxicity evaluation of highly functionalized pyranochromenes and pyranopyrans
| Autor: | Jagadeesh Babu Nanubolu, Krishnaiah Atmakur, Narender Reddy Emmadi, Sujitha Pombala, Ganesh Kumar Chityal |
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| Rok vydání: | 2012 |
| Předmět: |
Cell Survival
Clinical Biochemistry Molecular Conformation Pharmaceutical Science Moderate activity Crystallography X-Ray Biochemistry HeLa chemistry.chemical_compound Cell Line Tumor Drug Discovery Cervical carcinoma Humans Cytotoxic T cell Benzopyrans skin and connective tissue diseases Cytotoxicity Molecular Biology Pyrans biology Chemistry Organic Chemistry biology.organism_classification Molecular biology In vitro Pyran MCF-7 Cells Molecular Medicine Human breast HeLa Cells |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 22:7261-7264 |
| ISSN: | 0960-894X |
| DOI: | 10.1016/j.bmcl.2012.09.018 |
| Popis: | A series of fluorinated tetrahydropyrano[3,2-c]chromenes and dihydropyrano[3,2-b]pyran derivatives have been synthesized and their in vitro cytotoxic activities have been determined in cervical cancer cell line (HeLa), human breast adenocarcinoma cell line (MDA-MB-231 and MCF-7) and human alveolar adenocarcinoma cell line (A549). Compounds 4g, 4k, 4p showed a very potent activity against MDA-MB-231, and 4c, 4p showed promising activity against MCF-7, while compounds 4c, 4g, 4p showed moderate activity against HeLa. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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