Does adenosine play a role in bone formation, resorption and repair?
| Autor: | Bronwen Alice James Evans |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Male
Adenosine Time Factors Genotype Receptor Adenosine A2A Bone disease Osteocalcin Biology Receptor Adenosine A2B Transfection Bone remodeling Mice Cellular and Molecular Neuroscience Osteogenesis Bone cell medicine Animals Humans Integrin-Binding Sialoprotein Femur 5'-Nucleotidase Molecular Biology Mice Knockout Osteoblasts Tibia Mesenchymal stem cell Highlights in Purinergic Signalling Cell Differentiation Osteoblast 3T3 Cells X-Ray Microtomography Cell Biology Purinergic signalling medicine.disease Adenosine A2 Receptor Antagonists Mice Inbred C57BL Bone Diseases Metabolic Phenotype medicine.anatomical_structure Neuroscience Biomarkers Adenosine A2B receptor Signal Transduction medicine.drug |
| Zdroj: | Purinergic Signalling. 8:177-180 |
| ISSN: | 1573-9546 1573-9538 |
| Popis: | There has been increasing interest recently in the role purinergic signalling in the physiology and pathophysiology of musculoskeletal tissues, especially bone. Whereas the role of ATP in bone metabolism [1, 2] has been revealed to some extent and quite a few papers have been published in this respect, functions of its metabolite adenosine are not understood. Bone remodelling is a continuous, life-long process that maintains skeletal integrity. It is orchestrated by the three bone cell types (osteoblasts, osteoclasts and osteocytes), and impairments eventually result in diseases such as osteoporosis. Although there is much insight into the systems that maintain healthy bone, there is still a need to develop new therapies. The hypothesis that the adenosine signalling pathways might provide new targets for bone disease has gained further momentum recently with the publication of the following two papers that are commented on by Bronwen A. J. Evans of Cardiff University. Interestingly enough, the first article deals with findings obtained using CD73 null mice, that have also been the subject of another recently published Highlight [3] that focused on the role of local and systemic adenosine in modulation of antitumour responses in vivo. Here, CD73 null mice have been exploited to unveil a potential role of adenosine in osteoblast differentiation. In the second commented article, by using adenosine A2B receptor knockout mice, this receptor is identified as a main target for adenosine in promoting the differentiation of mesenchymal stem cell to osteoblasts. |
| Databáze: | OpenAIRE |
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