Differential expression of enteric neuroimmune-network in invasive and acute watery diarrhoea
| Autor: | A. E. Bishop, Jan Andersson, Birgitta Agerberth, Taufiqur Rahman Bhuiyan, Nurul Alam, Minnie M. Mathan, Protim Sarker, B. Wretlind, Firdausi Qadri, Rubhana Raqib |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Diarrhea Male medicine.medical_specialty Shigellosis Serotonin Adolescent Physiology media_common.quotation_subject Biopsy Vasoactive intestinal peptide Neuropeptide Biology Substance P medicine.disease_cause Enteric Nervous System chemistry.chemical_compound Young Adult Cholera Internal medicine Nerve Growth Factor medicine Humans Neurotransmitter media_common Dysentery Bacillary Neurons Endocrine and Autonomic Systems Convalescence Gastroenterology Rectum Vibrio cholerae O1 Middle Aged medicine.disease Endocrinology Nerve growth factor chemistry Vibrio cholerae Enteric nervous system Ubiquitin Thiolesterase Histamine Vasoactive Intestinal Peptide |
| Zdroj: | Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. 22(1) |
| ISSN: | 1365-2982 |
| Popis: | We aimed to evaluate the changes of nerve morphology and distribution of neurotransmitters and neuropeptides in the rectum of Shigella flexneri-infected patients and in the duodenum of Vibrio cholerae O1-infected patients. Nerve morphology was observed by transmission electron microscopy. Immunoreactivity of nerve growth factor (NGF), neurotransmitters and neuropeptides in tissues were studied by immunohistochemistry. Ultrastructural analysis of intestinal biopsy revealed persisting axons degeneration throughout the study period in all patients. Regeneration was already evident at the acute stage with marked increase at late convalescence. Both acute shigellosis and cholera were accompanied by increased expression of NGF and histamine and decreased expression of serotonin that was restored at convalescence. Immunoreactivity of vasoactive intestinal peptide (VIP) was increased during acute cholera, whereas in shigellosis VIP- and substance P-immunoreactive nerves appeared at early convalescence. Both shigellosis and cholera induced long-lasting degeneration of enteric neuronal axons, despite the presence of ongoing proliferation and regeneration processes. Neurotransmitters and neuropeptides may play differential roles in invasive and watery diarrhoea. |
| Databáze: | OpenAIRE |
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