Impaired microvascular reactivity after eccentric muscle contractions is not restored by acute ingestion of antioxidants or dietary nitrate

Autor:	Thomas Graven-Nielsen, Jens Myrup Thomsen, Rogerio Pessoto Hirata, Ryan Godsk Larsen, Jens Brøndum Frøkjær, Eva R. Poulsen, Rudi Steffensen
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	Cardiovascular Conditions Disorders and Treatments Adult Male medicine.medical_specialty Skeletal Muscle Physiology Hyperemia 030204 cardiovascular system & hematology Beetroot Juice medicine.disease_cause Placebo blood oxygen level dependent (BOLD) lcsh:Physiology Antioxidants Nitric oxide 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine muscle damage nitric oxide Physiology (medical) Internal medicine Isometric Contraction medicine Ingestion Eccentric oxidative stress Humans Beetroot juice Muscle Skeletal Nutrition Original Research Blood-oxygen-level dependent lcsh:QP1-981 business.industry Microcirculation Fruit and Vegetable Juices Vasodilation chemistry Cuff Microvessels Cardiology Female hyperemia Beta vulgaris business Muscle Contraction and Relaxation 030217 neurology & neurosurgery Oxidative stress
Zdroj:	Physiological Reports Larsen, R G, Thomsen, J M, Hirata, R P, Steffensen, R, Poulsen, E R, Frøkjær, J B & Graven-Nielsen, T 2019, ' Impaired microvascular reactivity after eccentric muscle contractions is not restored by acute ingestion of antioxidants or dietary nitrate ', Physiological Reports, vol. 7, no. 13, e14162 . https://doi.org/10.14814/phy2.14162 Physiological Reports, Vol 7, Iss 13, Pp n/a-n/a (2019)
ISSN:	2051-817X
DOI:	10.14814/phy2.14162
Popis:	Unaccustomed eccentric exercise leads to impaired microvascular function but the underlying mechanism is unknown. In this study, we evaluated the role of oxidative stress and of nitric oxide (NO) bioavailability. Thirty young men and women performed eccentric contractions of the tibialis anterior (TA) muscle (ECC), with the contralateral leg serving as nonexercising control (CON). Participants were randomized into three groups ingesting an antioxidant cocktail (AO), beetroot juice (BR) or placebo 46 h postexercise. At baseline and 48 h postexercise, hyperemic responses to brief muscle contractions and 5 min of cuff occlusion were assessed bilaterally in the TA muscles using blood oxygen level dependent (BOLD) magnetic resonance imaging. Eccentric contractions resulted in delayed time-to-peak (~22%; P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c332082f6d67bd19b291b846fc05c647 http://europepmc.org/articles/PMC6640596 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.