Prevalence and functional significance of 25-hydroxyvitamin D deficiency and vitamin D receptor gene polymorphisms in Asian Indians
| Autor: | Nikhil Tandon, Madhava Rao Vupputuri, Neeta Kumar, Nandita Gupta, Ravinder Goswami, Debarti Ray |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
musculoskeletal diseases
Adult Male medicine.medical_specialty TaqI Genotype Urban Population Medicine (miscellaneous) Parathyroid hormone India Rickets Calcitriol receptor Polymorphism Single Nucleotide vitamin D deficiency Body Mass Index chemistry.chemical_compound Internal medicine Vitamin D and neurology medicine Prevalence Humans Vitamin D Nutrition and Dietetics Polymorphism Genetic biology business.industry medicine.disease Vitamin D Deficiency FokI Endocrinology chemistry Vitamin D3 Receptor Parathyroid Hormone biology.protein Receptors Calcitriol Female business |
| Zdroj: | The American journal of clinical nutrition. 83(6) |
| ISSN: | 0002-9165 |
| Popis: | Recent studies show a wide prevalence of hypovitaminosis D in Asian Indians.The objective was to assess the functional significance of 25-hydroxyvitamin D [25(OH)D] deficiency, vitamin D receptor (VDR) gene, and parathyroid hormone (PTH) gene polymorphisms in relation to bone mineral density (BMD) in urban Asian Indians.Serum total calcium, inorganic phosphorus, alkaline phosphatase, 25(OH)D, intact PTH, and BMD at lumbar spine, proximal femur, and forearm were measured in 105 adult subjects. The genotyping related to VDR (BsmI, FokI, and TaqI) and PTH (BstBI and DraII) gene single-nucleotide polymorphisms was carried out by polymerase chain reaction-restriction fragment length polymorphism analysis.The mean serum 25(OH)D concentration in the whole cohort was 9.8 +/- 6.0 ng/mL, which was inversely related with serum intact PTH values (P = 0.042). Ninety-nine (94.3%) of the 105 subjects had vitamin D deficiency with 25(OH)D concentrations20 ng/mL. The age- and body mass index (BMI)-adjusted BMD value at the hip was higher in subjects with serum 25(OH)D values9.0 ng/mL than in those with valuesor = 9.0 ng/mL (0.893 +/- 0.114 compared with 0.839 +/- 0.112 g/cm2, respectively; P = 0.001). The mean forearm and spine BMD values in subjects with TT (VDR, TaqI) or bb (PTH, BstBI) genotypes were significantly higher than the values in subjects with Tt genotype and BB or Bb genotype, respectively.Functionally significant 25(OH)D deficiency affecting BMD at the hip region is prevalent in urban Asian Indians. However, variation in BMD at the spine and forearm is related to VDR and PTH gene polymorphisms rather than to vitamin D status, at least in this hypovitaminotic D population. |
| Databáze: | OpenAIRE |
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