| Autor: |
Rebecca Sunenshine, Diane Buell, Martin Fenstersheib, Christopher Shepherd, Margie Morgan, Cheri Grigg, Rebecca Fisher, Marc Fischer, Isaac Benowitz, Rebecca C. Woodruff, Isaac Ghinai, Brandon Bonin, John T. Watson, Kelly Lo, Shifaq Kamili, Olivia Almendares, Glenn E. Mathisen, Catherine M. Brown, Lynn Mello, Ruth N. Moro, Matthew Westercamp, Hannah L Kirking, Brian Rha, Sara Cody, Alison M. Binder, Moon Kim, Dawn Terashita, Sarah Scott, Joana Y Lively, Lauren Epstein, Holly M. Biggs, Shanon Smith, Timothy M. Uyeki, Jan King, Manisha Patel, Marielle J Fricchione, Aron J. Hall, Alicia P. Budd, Krista Queen, Vaughn Barry, Lindsay Kim, Kevin Chatham-Stephens, Kathleen Harriman, Francisco N Alvarez, Melissa A Rolfes, Mark A. Pallansch, Karen K. Wong, Anna R Yousaf, Jennifer P Collins, Graham Gerrard, Chelsea Foo, Ying Tao, Jennifer O'Shea, Miwako Kobayashi, Elizabeth Traub, Jeffrey D. Gunzenhauser, Megan J. Wallace, Heather Reese, Stephanie A Kujawski, Elsa Villarino, Azaibi Tamin, Olivia L McGovern, Keith Erickson, Xiaoyan Lu, Michelle Livingston, Lawrence C. Madoff, Hollianne Bruce, Glen R. Abedi, N Seema Ahmed, Oren Friedman, Matthew Zahn, Nora Chea, Susan Robinson, Matthew Donahue, Bryan Stierman, Thomas Haupt, Sarah Wilkerson, Rachel Bystritsky, Melissa M. Garcia, Sarah L. Rudman, Kayla N. Anderson, Jonathan Bryant-Genevier, Suxiang Tong, Victoria T Chu, Jennifer R. Verani, Jennifer C. Hunter, Mariel Marlow, Satish K. Pillai, Massimo Pacilli, Janell Routh, Amy Xie, Kiran Joshi, Anna Uehara, Howard Chiou, Vishal Dasari, Nancy McClung, Regina Sy-Santos, Jonathan M. Wortham, Michael Ben-Aderet, Patrick Dawson, Meredith Haddix, Gary I. Gutkin, Claire M Midgley, Sung-Sil Moon, Ahmet Tural, Jeremy A. Falk, Shannon A. Novosad, William V. Stoecker, Lindsey M. Duca, Janna Murray, Isabel Pedraza, Rachel Rubin, Michael A. Jhung, Michelle Holshue, Anna Kocharian, Amber K. Haynes, Romeo R. Galang, Gregory Marks, Traci DeSalvo, Jennifer L Harcourt, Karri Bartlett, Lijuan Wang, Jennifer E Layden, Alicia M. Fry, Mathew D. Esona, Erin E. Conners, Philip Robinson, George A. Diaz, Susa I. Gerber, George S Han, Suzanne Evans, Prabhu Gounder, Audrey Meier, Brian Lynch, Senthilkumar K. Sakthivel, Tiffany Wu, Jordan Cates, Talia Pindyck, Yan Li, Kenneth Komatsu, Stephanie R. Black, Mitali Mehta, Varun Shetty, Claire Jarashow, Brett Whitaker, Max W. Jacobs, E. Matt Charles, Scott Lindquist, Clinton R. Paden, Amanda Kita-Yarbro, Max Cohen, Sharon Balter, Talar Kamali, Heather J. Rhodes, Ethan A. Smith, Ruth Link-Gelles, Jing Zhang, Sajan Patel, Rachel Klos, Marie E Killerby, Grace M Vahey, Natalie J. Thornburg, Suzanne Donovan, Cora Hoover, Tristan D. McPherson, Aaron T. Curns, Nichole Quick, Sara E. Oliver, Demian Christiansen, Ram Koppaka, Jonathan Grein, Rekha Murthy, Leora R. Feldstein, Karlyn D. Beer, Jennifer Lo, Stephen Lindstrom, Lakshmi Malapati, Ian W. Pray |
| Rok vydání: |
2020 |
| Předmět: |
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| Popis: |
IntroductionMore than 93,000 cases of coronavirus disease (COVID-19) have been reported worldwide. We describe the epidemiology, clinical course, and virologic characteristics of the first 12 U.S. patients with COVID-19.MethodsWe collected demographic, exposure, and clinical information from 12 patients confirmed by CDC during January 20–February 5, 2020 to have COVID-19. Respiratory, stool, serum, and urine specimens were submitted for SARS-CoV-2 rRT-PCR testing, virus culture, and whole genome sequencing.ResultsAmong the 12 patients, median age was 53 years (range: 21–68); 8 were male, 10 had traveled to China, and two were contacts of patients in this series. Commonly reported signs and symptoms at illness onset were fever (n=7) and cough (n=8). Seven patients were hospitalized with radiographic evidence of pneumonia and demonstrated clinical or laboratory signs of worsening during the second week of illness. Three were treated with the investigational antiviral remdesivir. All patients had SARS-CoV-2 RNA detected in respiratory specimens, typically for 2–3 weeks after illness onset, with lowest rRT-PCR Ct values often detected in the first week. SARS-CoV-2 RNA was detected after reported symptom resolution in seven patients. SARS-CoV-2 was cultured from respiratory specimens, and SARS-CoV-2 RNA was detected in stool from 7/10 patients.ConclusionsIn 12 patients with mild to moderately severe illness, SARS-CoV-2 RNA and viable virus were detected early, and prolonged RNA detection suggests the window for diagnosis is long. Hospitalized patients showed signs of worsening in the second week after illness onset. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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