Add-on high frequency deep transcranial magnetic stimulation (dTMS) to bilateral prefrontal cortex reduces cocaine craving in patients with cocaine use disorder
| Autor: | Alessandro Vento, Stefano Ferracuti, Simone Di Pietro, Roberto Brugnoli, Georgios D. Kotzalidis, Gloria Angeletti, Daria Piacentino, Vittoria Rachele Ferri, Paolo Girardi, Antonio Del Casale, Gabriele Sani, Ruggero N. Raccah, Abraham Zangen, Chiara Rapinesi |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Visual analogue scale medicine.medical_treatment cocaine use disorder craving deep transcranial magnetic stimulation (dTMS) dorsolateral prefrontal cortex (DLPFC) Prefrontal Cortex Craving Functional Laterality Cocaine dependence Nicotine 03 medical and health sciences Cocaine-Related Disorders 0302 clinical medicine mental disorders medicine Humans Deep transcranial magnetic stimulation Prefrontal cortex General Neuroscience Middle Aged medicine.disease Transcranial Magnetic Stimulation 030227 psychiatry Dorsolateral prefrontal cortex Transcranial magnetic stimulation medicine.anatomical_structure Anesthesia Female medicine.symptom Psychology 030217 neurology & neurosurgery medicine.drug |
| Popis: | Cocaine dependence is a substantial public health problem. The aim of this study is to evaluate the effect of high frequency deep transcranial magnetic stimulation (dTMS) on craving in patients with cocaine use disorder (CUD).Seven men (mean age, 48.71 years; standard deviation [SD], 9.45; range 32-60 years) with CUD and no concurrent axis 1 or 2 disorder save nicotine abuse, underwent three sessions of alternate day 20Hz dTMS in 20 trains delivered to the dorsolateral prefrontal cortex (DLPFC) preferentially to the left hemisphere, for 12 sessions spread over one month, added to unchanged prior drug treatment. We used a visual analogue scale (VAS) to measure cocaine craving the week before, each week during, and one month after dTMS treatment.DLPFC stimulation significantly reduced craving over time: within-subjects main effect of time of treatment (ANOVA, F[3,18]=46.154; p0.001; η(2)=0.88). The reduction of craving from baseline was significant at two weeks (p0.001), and four weeks (p0.001) of treatment, and at the week eight, four weeks after treatment interruption (p=0.003), although the increase of craving was significant from week four and eight (p=0.014).dTMS over left DLPFC reduced craving in CUD patients in a small sample that is to be considered preliminary. However, maintenance sessions would be needed to maintain the achieved results. Our findings highlight the potential of noninvasive neuromodulation as a therapeutic tool for cocaine addiction. |
| Databáze: | OpenAIRE |
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