Meroterpenoids from a Medicinal Fungus Antrodia cinnamomea
| Autor: | Mei Chuan Chen, Ting Yu Cho, Tzong-Huei Lee, Yueh-Hsiung Kuo |
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| Rok vydání: | 2017 |
| Předmět: |
Stereochemistry
Ubiquinone Taiwan Pharmaceutical Science Alcoholic intoxication Growth inhibitory Fungus 01 natural sciences Analytical Chemistry Structure-Activity Relationship 4-Butyrolactone Drug Discovery Structure–activity relationship Humans Spectral analysis Antroquinonol B Pharmacology Traditional medicine biology Molecular Structure 010405 organic chemistry Cyclohexanones Terpenes Organic Chemistry Fungi biology.organism_classification 0104 chemical sciences 010404 medicinal & biomolecular chemistry Complementary and alternative medicine Antroquinonol Antrodia Molecular Medicine Fluorouracil Antrodia cinnamomea |
| Zdroj: | Journal of natural products. 80(9) |
| ISSN: | 1520-6025 |
| Popis: | Antrodia cinnamomea, a medicinal fungus indigenous to Taiwan, has been shown to exhibit a broad spectrum of bioactivities for the treatments of alcoholic intoxication, diarrhea, abdominal pain, and fatigue, and a number of active principles have been identified. Among the bioactive entities, clinical trials of antroquinonol and 4-acetyl antroquinonol B are being carried out for curing cancer, hypercholesterolemia, and hyperlipidemia. The total synthesis of antroquinonol has been achieved; however, investigating the structure-activity relationship of this class of compounds remained difficult due to the lack of available analogues. Twenty antroquinonols isolated from A. cinnamomea IFS006 are reported herein. Their structures were elucidated using spectral analysis and by comparison with literature values. Of these, 11 antroquinonol analogues, namely, antroquinonols N-X (1-11), were previously unreported. The growth inhibitory activity of all the antroquinonol analogues was evaluated against human A549 and PC-3 cancer cell lines, and antroquinonol A exhibited the most potent activity, with GI |
| Databáze: | OpenAIRE |
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