Change in volume parameters induced by neoadjuvant chemotherapy provide accurate prediction of overall survival after resection in patients with oesophageal cancer
| Autor: | Matthias Paireder, Richard M. Gore, Sebastian F. Schoppmann, Barbara Fueger, Dietmar Tamandl, Michael Hejna, Alexander Haug, Ahmed Ba-Ssalamah, Patrick Kinsperger |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Surgical margin medicine.medical_specialty Esophageal Neoplasms medicine.medical_treatment Multimodal Imaging 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Fluorodeoxyglucose F18 Medicine Humans Radiology Nuclear Medicine and imaging Neuroradiology Aged Proportional Hazards Models Retrospective Studies Aged 80 and over Chemotherapy medicine.diagnostic_test business.industry Proportional hazards model Hazard ratio Cancer Interventional radiology General Medicine Middle Aged medicine.disease Prognosis Confidence interval Neoadjuvant Therapy Tumor Burden Esophagectomy Chemotherapy Adjuvant 030220 oncology & carcinogenesis Positron-Emission Tomography Female Radiology business Tomography X-Ray Computed Glycolysis |
| Zdroj: | European radiology. 26(2) |
| ISSN: | 1432-1084 |
| Popis: | To assess the prognostic value of volumetric parameters measured with CT and PET/CT in patients with neoadjuvant chemotherapy (NACT) and resection for oesophageal cancer (EC). Patients with locally advanced EC, who were treated with NACT and resection, were retrospectively analysed. Data from CT volumetry and 18 F-FDG PET/CT (maximum standardized uptake [SUVmax], metabolic tumour volume [MTV], and total lesion glycolysis [TLG]) were recorded before and after NACT. The impact of volumetric parameter changes induced by NACT (MTVRATIO, TLGRATIO, etc.) on overall survival (OS) was assessed using a Cox proportional hazards model. Eighty-four patients were assessed using CT volumetry; of those, 50 also had PET/CT before and after NACT. Low post-treatment CT volume and thickness, MTV, TLG, and SUVmax were all associated with longer OS (p |
| Databáze: | OpenAIRE |
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