Synergism of Telmisartan and Amlodipine on Blood Pressure Reduction and Cardiorenal Protection in Hypertensive Rats
| Autor: | Ai-Jun Liu, Hao Zhang, Xiao-Fei Gu, Shu-Wei Song, Wei Wang, Wei Liu, Ding-Feng Su, Feng-Yun Su, Xiu-Juan Ma |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Male
Cardiotonic Agents Time Factors Kidney Glomerulus Angiotensin-Converting Enzyme Inhibitors Blood Pressure Pharmacology Kidney Benzoates Rats Sprague-Dawley Atrophy Renal injury Fibrosis Intragastric administration Rats Inbred SHR medicine Animals Telmisartan Amlodipine Antihypertensive Agents Dose-Response Relationship Drug business.industry Drug Synergism Calcium Channel Blockers medicine.disease Rats Disease Models Animal Blood pressure Myocardial hypertrophy Hypertension Benzimidazoles Drug Therapy Combination Kidney Diseases Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Journal of Cardiovascular Pharmacology. 57:308-316 |
| ISSN: | 0160-2446 |
| DOI: | 10.1097/fjc.0b013e3182073e41 |
| Popis: | AIM This study was designed to investigate the effects of telmisartan and amlodipine on reduction of blood pressure (BP), myocardial hypertrophy, and renal injury in hypertensive rats. METHOD In acute experiments, the BP was measured in conscious freely moving rats. Spontaneously hypertensive rats were treated with intragastric administration of amlodipine (1, 2, 4 mg/kg), telmisartan (4, 8, 12, 16, 20 mg/kg), and their different combinations (4 + 4, 2 + 4, 4 + 8, 4 + 12, 1 + 4, 2 + 8, 4 + 16, 2 + 12, 1 + 8, 2 + 16, 2 + 20, 1 + 12, 1 + 16, 1 + 20 mg/kg). The probability sum test (q test) was used to evaluate the synergistic action on BP reduction. In two-kidney, one-clip rats, the effects of amlodipine (1 mg/kg), telmisartan (6 mg/kg) and their combination on BP reduction were observed. In the chronic study, spontaneously hypertensive rats were treated with amlodipine (1 mg/kg), telmisartan (6 mg/kg), and their combination for 4 months. Histopathologic examinations were performed after the determination of BP and BP variability. RESULTS There is a synergistic interaction between amlodipine and telmisartan on BP reduction. The optimal dose ratio was found at 1:6. The synergistic effect of this dose ratio (1:6) was also seen in two-kidney, one-clip rats. Long-term treatment with this combination results in a beneficial effect on the reduction of BP and BP variability. The end-organ damage, including myocardial hypertrophy, glomerular atrophy, and fibrosis, was significantly attenuated by this combination. CONCLUSION The optimal dose ratio of amlodipine and telmisartan on BP was 1:6. This combination is beneficial for the BP and BP variability reduction and end-organ damage prevention. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|