Baseline thymic volume is a predictor for CD4 T cell repopulation in adult HIV-infected patients under highly active antiretroviral therapy
| Autor: | Juan Delgado, Amalia Rubio, Armando Sánchez-Quijano, Manuel Leal, Rafael de la Rosa, Manuel Martinez-Moya, Elena Merchante, Ezequiel Ruiz-Mateos, Eduardo Lissen |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Adult
CD4-Positive T-Lymphocytes Male Anti-HIV Agents medicine.medical_treatment HIV Infections Thymus Gland Virus Acquired immunodeficiency syndrome (AIDS) Immunopathology Antiretroviral Therapy Highly Active Medicine Humans Pharmacology (medical) Sida Pharmacology Chemotherapy biology business.industry HIV T lymphocyte biology.organism_classification medicine.disease CD4 Lymphocyte Count Infectious Diseases Organ Specificity Lentivirus Immunology Female Viral disease business |
| Zdroj: | Publons Juan Delgado-Cuesta Scopus-Elsevier |
| ISSN: | 1359-6535 |
| Popis: | The objective of the present study was to assess the impact of baseline thymic volume on the CD4 cell repopulation induced by highly active antiretroviral therapy (HAART) in HIV-infected adults. Therefore, 37 previously untreated HIV-1-infected adults were prospectively followed from August 1998 to September 2001. All patients underwent a thorax CT scan at starting HAART to measure thymic volume. The median follow-up time was 189 [87.5–498.5] days. CD4 cell repopulation was considered as an increase ≥200 cells/mm3 above baseline count. Twenty-one (57%) patients achieved this CD4 repopulation. Baseline thymic volume was the main independent factor associated with CD4 repopulation ( P=0.016); this factor was a positive predictor (adjusted hazard ratio: 1.25 [95% confidence interval 1.1–1.4]). Although, CD4 cell count and non-AIDS diagnosis at baseline were associated with CD4 cell repopulation on the univariate analysis ( P=0.03 and P=0.02, respectively), no statistical signification was found on the multivariate test. In summary, baseline thymic volume is a predictor of early CD4 cell repopulation in adult HIV-1-infected patients taking HAART. |
| Databáze: | OpenAIRE |
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